Document Detail

Obstructive sleep apnoea: longer respiratory event lengths in patients with heart failure.
MedLine Citation:
PMID:  23018907     Owner:  NLM     Status:  Publisher    
This study investigated the effect of heart failure (HF) on respiratory patterns in patients with obstructive sleep apnoea (OSA).Thirty-nine patients with established OSA (apnoea-hypopnoea index [AHI] >10·h(-1)) and with HF (NYHA II+III, LVEF ≤40%; n=26, age 67±9 years) or without HF (LVEF ≥50%, NT-proBNP <400 ;pg·mL(-1); n=13, age 73±6 years) underwent simultaneous right- and left-heart catheterization within 12 ;h of cardiorespiratory polygraphy recording.Respiratory patterns of OSA were significantly longer in OSA patients with versus without HF, including cycle length (CL; 46.0±10.0 vs 37.8±10.6 sec; p=0.024), ventilation length (VL; 25.4±6.3 vs 21.3±7.1 sec; p=0.044), apnoea length (AL; 20.5±4.9 vs 16.5±3.9 sec; p=0.013), time-to-peak ventilation (TTPV; 10.6±3.0 vs 8.3±2.5 sec; p=0.021) and circulatory delay (CD; 28.5±7.5 vs 22.6±3.7 sec; p=0.005). Positive and robust correlations were found between some of these parameters and the degree of congestion in HF; CL (r=0.53; p=0.006), VL (r=0.55; p=0.004) and TTPV (r=0.47; p=0.015) all increased with a rise in pulmonary capillary wedge pressure.Respiratory patterns in OSA appear to be dependent on cardiac function, with an increase in event lengths as cardiac function decreases. In patients with HF, some of these events correlate with the degree of pulmonary congestion.
Christina Efken; Thomas Bitter; Natalie Prib; Dieter Horstkotte; Olaf Oldenburg
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-27
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Heart and Diabetes Centre North Rhine - Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany.
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