Document Detail


Obstructive sleep apnea and hypertension: mechanisms, evaluation, and management.
MedLine Citation:
PMID:  18367017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obstructive sleep apnea (OSA) is a recognized cause of secondary hypertension. OSA episodes produce surges in systolic and diastolic pressure that keep mean blood pressure levels elevated at night. In many patients, blood pressure remains elevated during the daytime, when breathing is normal. Contributors to this diurnal pattern of hypertension include sympathetic nervous system overactivity and alterations in vascular function and structure caused by oxidant stress and inflammation. Treatment of OSA with nasal continuous positive airway pressure (CPAP) abolishes apneas, thereby preventing intermittent arterial pressure surges and restoring the nocturnal "dipping" pattern. CPAP treatment also has modest beneficial effects on daytime blood pressure. Because even small decreases in arterial pressure can contribute to reducing cardiovascular risk, screening for OSA is an essential element of evaluating patients with hypertension.
Authors:
John M Dopp; Kevin J Reichmuth; Barbara J Morgan
Related Documents :
7608817 - Use of nasal continuous positive airway pressure as treatment of childhood obstructive ...
453777 - Determination of specific airway conductance by a simplified plethysmographic procedure.
8365287 - Nasal continuous positive airway pressure in decompensated hypercapnic respiratory fail...
15667797 - Effects of antihypertensives on arterial responses associated with obstructive sleep ap...
12744767 - Eradication of methicillin-resistant staphylococcus aureus from pressure sores using wa...
25416657 - Estimated gfr or albuminuria: which one is really associated with resistant hypertension?
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Current hypertension reports     Volume:  9     ISSN:  1522-6417     ISO Abbreviation:  Curr. Hypertens. Rep.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888982     Medline TA:  Curr Hypertens Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  529-34     Citation Subset:  IM    
Affiliation:
Department of Orthopedics and Rehabilitation, Madison, WI 53706, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Diastole
Humans
Hypertension / etiology*,  physiopathology
Risk Factors
Sleep Apnea, Obstructive / complications*,  drug therapy,  physiopathology,  therapy
Systole
Grant Support
ID/Acronym/Agency:
K12 RR 023268/RR/NCRR NIH HHS; R0-1 HL-074072/HL/NHLBI NIH HHS; T32 HL 07654/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Adrenal steroids and the metabolic syndrome.
Next Document:  Severe paroxysmal hypertension (pseudopheochromocytoma).