Document Detail

Obstructive sleep apnea and hypertension: from correlative to causative relationship.
MedLine Citation:
PMID:  11588408     Owner:  NLM     Status:  MEDLINE    
Sleep-disordered breathing, manifested by repetitive episodes of partial or complete cessation of breathing during sleep associated with brief arousal and autonomic activation, is estimated to affect as many as 4% of adult men and 2% of adult women. Studies conducted during the 1980s revealed a strong association between sleep-disordered breathing and hypertension. The results of these early studies, which relied on relatively small samples of patients, have been confirmed in recent years by large-scale epidemiologic studies that are controlled for all possible confounding factors. This paper reviews the evidence suggesting a causative relationship between hypertension and disordered breathing in sleep. The authors discuss the possible underlying mechanisms of the two entities and address the clinical implications of this relationship. They conclude by recommending a proactive approach to the diagnosis of breathing disorders in sleep, in order to prevent the cardiovascular sequelae of this syndrome.
P Lavie; D Silverberg; A Oksenberg; V Hoffstein
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  3     ISSN:  1524-6175     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:    2001 Sep-Oct
Date Detail:
Created Date:  2001-10-05     Completed Date:  2001-12-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  296-301     Citation Subset:  IM    
Sleep Laboratory, Faculty of Medicine,Technion-Israel Institute of Technology, Haifa, Israel.
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MeSH Terms
Confounding Factors (Epidemiology)
Hypertension / epidemiology,  etiology*,  prevention & control
Risk Factors
Sleep Apnea, Obstructive / complications*,  physiopathology,  therapy

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