Document Detail


Obstructive sleep apnea is highly prevalent and correlates with impaired glycemic control in consecutive patients with the metabolic syndrome.
MedLine Citation:
PMID:  19614795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Obstructive sleep apnea (OSA) and the metabolic syndrome (MS) are independently associated with increased cardiovascular risk. The objective of the present study was to determine the prevalence of OSA among consecutive patients with MS and to determine whether OSA is associated with impaired glycemic control. Fifty consecutive patients with a recent diagnosis of MS and no previous diagnosis of OSA underwent a polysomnography and anthropometric and laboratory measurements. The prevalence of OSA (apnea-hypopnea index >or=15 events per hour of sleep) was 68% and in the same range of all other individual components of MS. Moreover, OSA was associated with increased levels of glucose (P=.03) and glycosylated hemoglobin (P=.03) but not with body mass index (P=.30). Glycosylated hemoglobin was independently associated with glucose (P<.001) and apnea-hypopnea index (P=.03). The prevalence of OSA is in the same range as all the individual components of MS and is independently associated with impaired glycemic control.
Authors:
Luciano F Drager; Eduardo L Queiroz; Heno F Lopes; Pedro R Genta; Eduardo M Krieger; Geraldo Lorenzi-Filho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the cardiometabolic syndrome     Volume:  4     ISSN:  1559-4572     ISO Abbreviation:  -     Publication Date:  2009  
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101284690     Medline TA:  J Cardiometab Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  89-95     Citation Subset:  IM    
Affiliation:
Hypertension Unit, University of São Paulo Medical School, São Paulo, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Blood Glucose / metabolism
Body Mass Index
Cross-Sectional Studies
Female
Hemoglobin A, Glycosylated / metabolism
Humans
Hyperglycemia / blood,  epidemiology*,  physiopathology
Male
Metabolic Syndrome X / blood,  epidemiology*,  physiopathology
Middle Aged
Polysomnography
Prevalence
Severity of Illness Index
Sleep Apnea, Obstructive / blood,  epidemiology*,  physiopathology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/hemoglobin A1c protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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