| Obstructive primary bladder neck disease: evaluation of the efficacy and safety of alpha1-blockers. | |
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MedLine Citation:
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PMID: 16493217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The efficacy and safety of using alpha(1)-adrenergic blockers for treating primary bladder neck obstruction in young and middle-aged men was assessed as the first therapeutic step, before surgery, in a symptomatic non-neurogenic selected group of patients. MATERIALS AND METHODS: From January 1995 to December 2001, primary bladder neck obstruction was diagnosed in 41 men whose average age was 43 years. All of them were evaluated by a complete clinical history, American Urological Association (AUA) symptom score index, physical examination, uroflowmetry, transabdominal ultrasound prostatic volume determination, ultrasound post-void residual determination, videourodynamics including pressure-flow analysis and upper urinary tract screening with renal ultrasound or an excretory urogram. A full daily dose of alpha(1)-adrenergic blockers (alfuzosin or tamsulosin) was administered for at least 6 months. Successful treatment was defined as improved symptoms, voiding diary, maximum flow rate and pressure-flow parameters. Patients who did not gain improvement of symptoms with pharmacological treatment were offered surgery. RESULTS: Overall, pharmacological treatment was successful in 29/41 patients (70.7%) whereas bladder neck endoscopic incision was mandatory in 12/41 (29.3%). CONCLUSIONS: alpha(1)-Blockers were effective and safe for treating young and middle-aged men with symptomatic bladder neck obstruction. |
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Authors:
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A Cisternino; G Zeccolini; A Calpista; V De Marco; T Prayer Galetti; M Iafrate; W Artibani |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Urologia internationalis Volume: 76 ISSN: 0042-1138 ISO Abbreviation: Urol. Int. Publication Date: 2006 |
Date Detail:
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Created Date: 2006-02-22 Completed Date: 2006-08-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0417373 Medline TA: Urol Int Country: Switzerland |
Other Details:
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Languages: eng Pagination: 150-3 Citation Subset: IM |
Affiliation:
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Department of Urology, University of Padua, Padua, Italy. antonio.cisternino@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Antagonists
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adverse effects,
therapeutic use* Adult Humans Male Middle Aged Quinazolines / adverse effects, therapeutic use* Sulfonamides / adverse effects, therapeutic use* Time Factors Urinary Bladder Neck Obstruction / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Antagonists; 0/Quinazolines; 0/Sulfonamides; 106133-20-4/tamsulosin; 81403-80-7/alfuzosin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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