Document Detail

Obstructive primary bladder neck disease: evaluation of the efficacy and safety of alpha1-blockers.
MedLine Citation:
PMID:  16493217     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The efficacy and safety of using alpha(1)-adrenergic blockers for treating primary bladder neck obstruction in young and middle-aged men was assessed as the first therapeutic step, before surgery, in a symptomatic non-neurogenic selected group of patients. MATERIALS AND METHODS: From January 1995 to December 2001, primary bladder neck obstruction was diagnosed in 41 men whose average age was 43 years. All of them were evaluated by a complete clinical history, American Urological Association (AUA) symptom score index, physical examination, uroflowmetry, transabdominal ultrasound prostatic volume determination, ultrasound post-void residual determination, videourodynamics including pressure-flow analysis and upper urinary tract screening with renal ultrasound or an excretory urogram. A full daily dose of alpha(1)-adrenergic blockers (alfuzosin or tamsulosin) was administered for at least 6 months. Successful treatment was defined as improved symptoms, voiding diary, maximum flow rate and pressure-flow parameters. Patients who did not gain improvement of symptoms with pharmacological treatment were offered surgery. RESULTS: Overall, pharmacological treatment was successful in 29/41 patients (70.7%) whereas bladder neck endoscopic incision was mandatory in 12/41 (29.3%). CONCLUSIONS: alpha(1)-Blockers were effective and safe for treating young and middle-aged men with symptomatic bladder neck obstruction.
A Cisternino; G Zeccolini; A Calpista; V De Marco; T Prayer Galetti; M Iafrate; W Artibani
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Urologia internationalis     Volume:  76     ISSN:  0042-1138     ISO Abbreviation:  Urol. Int.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-22     Completed Date:  2006-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  150-3     Citation Subset:  IM    
Department of Urology, University of Padua, Padua, Italy.
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MeSH Terms
Adrenergic alpha-Antagonists / adverse effects,  therapeutic use*
Middle Aged
Quinazolines / adverse effects,  therapeutic use*
Sulfonamides / adverse effects,  therapeutic use*
Time Factors
Urinary Bladder Neck Obstruction / drug therapy*
Reg. No./Substance:
0/Adrenergic alpha-Antagonists; 0/Quinazolines; 0/Sulfonamides; 106133-20-4/tamsulosin; 81403-80-7/alfuzosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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