| Obstructive Sleep Apnea-Specific Quality of Life and Behavioral Problems in Children with Syndromic Craniosynostosis. | |
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MedLine Citation:
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PMID: 21297497 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: This study aimed at evaluating the impact of syndromic craniosynostosis on quality of life, assessing the association between the presence of craniosynostosis syndrome and prevalence of behavioral problems and assessing the impact of obstructive sleep apnea (OSA) in syndromic craniosynostosis compared with healthy controls. METHOD:: A prospective study was carried out using the Obstructive Sleep Apnea-18 (OSA-18) survey and Child Behavior Checklist (CBCL) in 119 syndromic craniosynostosis patients and the OSA-18 survey in 459 controls. The craniosynostosis population underwent a polysomnography to diagnose OSA. RESULTS:: The total OSA-18 score and scores on the domains sleep disturbance, physical suffering, and caregiver concerns were significantly higher in the craniosynostosis group than in controls. Subgroup analysis revealed behavioral problems in 67% and 50% of boys with Apert and Muenke syndrome, respectively. Correlations between obstructive apnea-hypopnea index and total OSA-18 and CBCL scores were significant. Mean scores for the domains sleep disturbance and physical suffering were significantly higher in moderate OSA. CONCLUSIONS:: OSA is related with a lower quality of life in children with syndromic craniosynostosis. Behavioral problems were more common in boys with Apert and Muenke syndrome. OSA-18 and CBCL scores were correlated with OSA severity. |
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Authors:
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Natalja Bannink; Marianne Maliepaard; Hein Raat; Koen F M Joosten; Irene M J Mathijssen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-3 |
Journal Detail:
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Title: Journal of developmental and behavioral pediatrics : JDBP Volume: - ISSN: 1536-7312 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006933 Medline TA: J Dev Behav Pediatr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Department of Plastic Surgery and Reconstructive Surgery and Pediatrics, Dutch Craniofacial Center, Erasmus Medical Center-Sophia Children's Hospital, Rotterdam, the Netherlands; †Department of Public Health, Erasmus Medical Center, Rotterdam, the Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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