Document Detail


Obstruction of the superior vena cava after neonatal extracorporeal membrane oxygenation: association with chylothorax and outcome of transcatheter treatment*.
MedLine Citation:
PMID:  23295835     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: : Obstruction of the superior vena cava is one of the potential complications of neonatal extracorporeal membrane oxygenation. Chylothorax is a known complication of surgery involving the thoracic cavity in children, and of extracorporeal membrane oxygenation. The aim of this study was to evaluate the association between chylothorax and superior vena cava obstruction after neonatal extracorporeal membrane oxygenation.
METHODS AND RESULTS: : Twenty-two patients diagnosed with superior vena cava obstruction at ≤6 months of age (median 1.8 months) after neonatal extracorporeal membrane oxygenation were compared with a randomly selected cohort of 44 neonatal extracorporeal membrane oxygenation patients without superior vena cava obstruction. Among patients with superior vena cava obstruction, 18 underwent extracorporeal membrane oxygenation for respiratory disease and four for cardiac insufficiency. Chylothorax was more prevalent among patients with superior vena cava obstruction than controls (odds ratio 9.4 [2.2-40], p = .01) and was associated with extension of obstruction into the left innominate vein. Patients with superior vena cava obstruction were supported by extracorporeal membrane oxygenation for a longer duration than controls. Nineteen patients with superior vena cava obstruction (86%) underwent transcatheter balloon angioplasty and/or stent implantation (median 7 days after diagnosis), which decreased the superior vena cava pressure and superior vena cava-to-right atrium pressure gradient and increased the superior vena cava diameter (all p < 0.001). There were no serious procedural adverse events. Six study patients died within 30 days of the diagnosis of superior vena cava obstruction (including three of nine with chylothorax), which did not differ from controls. During a median follow-up of 2.7 yrs, two additional patients died and nine underwent 14 superior vena cava reinterventions.
CONCLUSIONS: : Among neonates treated with extracorporeal membrane oxygenation, superior vena cava obstruction is associated with an increased risk of chylothorax. In neonates with chylothorax after extracorporeal membrane oxygenation, evaluation for superior vena cava obstruction may be warranted. Although mortality is high in this population, transcatheter treatment can relieve superior vena cava obstruction and facilitate symptomatic improvement.
Authors:
Selcen Yaroglu Kazanci; Doff B McElhinney; Ravi Thiagarajan; Lisa Bergersen; Jay M Wilson; Audrey C Marshall; James E Lock; Mary P Mullen
Related Documents :
11952185 - Cognitive-behavioral therapy for bulimia nervosa: time course and mechanisms of change.
22267705 - The influence of the initial width of the cleft in patients with unilateral cleft lip a...
25347635 - A systematic review comparing furlow double-opposing z-plasty and straight-line intrave...
23995765 - Changes in structure and symptoms in knee osteoarthritis and prediction of future knee ...
123715 - Management of massive abdominal wall defects.
17383335 - Practical regimen for amiodarone use in preventing postoperative atrial fibrillation.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  14     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-43     Citation Subset:  IM    
Affiliation:
1 Department of Cardiology, Children's Hospital and Pediatrics, Harvard Medical School, Boston, MA. 2 Department of Surgery, Children's Hospital and Surgery, Harvard Medical School, Boston, MA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Therapeutic hypothermia after pediatric cardiac arrest trials: the vanguard phase experience and im...
Next Document:  Nutritional Immunomodulation in Critically Ill Children With Acute Lung Injury: Feasibility and Impa...