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Obstetrical and fetal outcomes of a new management strategy in patients with intra-hepatic cholestasis of pregnancy.
MedLine Citation:
PMID:  20521062     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
PURPOSES: To determine the incidence, obstetrical, and fetal complication rates of intrahepatic cholestasis of pregnancy (ICP) in patients managed expectantly to 40-weeks gestation.
METHODS: In a prospective cohort study conducted between February 2008 and January 2010, a total of 21,960 pregnant women in Qassim Region of Saudi Arabia were screened for ICP using specific criteria for diagnosis. The course of pregnancy was monitored to 40-weeks gestation or spontaneous onset of labor, whichever comes first. The measured outcomes were compared with a cross-matched group of healthy pregnant women. Continuous variables were analyzed with t test, while χ(2) test was used for comparing percentages.
RESULTS: The incidence of ICP was 0.35% (76/21,960). There was no significant difference between groups in gestational age at delivery, preterm labor, intrauterine fetal death, cesarean section, or respiratory distress syndrome. There was significantly higher intrapartum non-reassuring fetal heart rate patterns and meconium-stained amniotic fluid in ICP group (P < 0.01 and <0.0001, respectively).
CONCLUSIONS: The incidence of ICP in this region is low compared to worldwide range. Expectant management to 40-weeks gestation is associated with obstetrical and fetal outcomes comparable to normal pregnancy; however, intrapartum fetal asphyxia is more likely.
Authors:
Hani A Al Shobaili; Hossam O Hamed; Ahmad Al Robaee; Abdullateef A Alzolibani; Ahmad F Amin; Salah R Ahmad
Publication Detail:
Type:  Journal Article     Date:  2010-06-04
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  283     ISSN:  1432-0711     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1219-25     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Qassim University, Qassim, Saudi Arabia.
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