| Obstetrical and fetal outcomes of a new management strategy in patients with intra-hepatic cholestasis of pregnancy. | |
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MedLine Citation:
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PMID: 20521062 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSES: To determine the incidence, obstetrical, and fetal complication rates of intrahepatic cholestasis of pregnancy (ICP) in patients managed expectantly to 40-weeks gestation. METHODS: In a prospective cohort study conducted between February 2008 and January 2010, a total of 21,960 pregnant women in Qassim Region of Saudi Arabia were screened for ICP using specific criteria for diagnosis. The course of pregnancy was monitored to 40-weeks gestation or spontaneous onset of labor, whichever comes first. The measured outcomes were compared with a cross-matched group of healthy pregnant women. Continuous variables were analyzed with t test, while χ(2) test was used for comparing percentages. RESULTS: The incidence of ICP was 0.35% (76/21,960). There was no significant difference between groups in gestational age at delivery, preterm labor, intrauterine fetal death, cesarean section, or respiratory distress syndrome. There was significantly higher intrapartum non-reassuring fetal heart rate patterns and meconium-stained amniotic fluid in ICP group (P < 0.01 and <0.0001, respectively). CONCLUSIONS: The incidence of ICP in this region is low compared to worldwide range. Expectant management to 40-weeks gestation is associated with obstetrical and fetal outcomes comparable to normal pregnancy; however, intrapartum fetal asphyxia is more likely. |
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Authors:
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Hani A Al Shobaili; Hossam O Hamed; Ahmad Al Robaee; Abdullateef A Alzolibani; Ahmad F Amin; Salah R Ahmad |
Publication Detail:
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Type: Journal Article Date: 2010-06-04 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: 283 ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-05-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: Germany |
Other Details:
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Languages: eng Pagination: 1219-25 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Qassim University, Qassim, Saudi Arabia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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