Document Detail

Obstetric risk factors and persistent increases in brain parenchymal echogenicity in preterm infants.
MedLine Citation:
PMID:  15327604     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the risk of persistent (>7 days) increases in brain parenchymal echogenicity in preterm infants and their association with known obstetric risk factors. DESIGN: Case-control study of prospectively collected data. SETTING: A University hospital in Northern Italy. POPULATION: Eighty-five singleton infants between 24 and 34 weeks of gestation with a cranial ultrasonographic diagnosis of persistently increased parenchymal echogenicity without development of cystic degeneration, and 170 control infants with negative cranial ultrasonographic findings. METHODS: A comparison of the prevalence of selected obstetric risk factors between infants with persistent echo-dense lesions and negative controls. MAIN OUTCOME MEASURES: Odds ratios of persistent echo-dense lesions including first-degree interactions between variables. RESULTS: After adjusting for birthweight, logistic regression analysis showed that the only factor associated with an increased risk of persistent brain echo-dense lesions in infants was multiple courses of antenatal steroids (OR = 2.14, 95% CI = 1.11-4.15, P= 0.024). In this group, the risk of persistent echo-dense lesions was particularly high in: (i) mothers receiving dexamethasone rather than betamethasone (P value for interaction = 0.015) and (ii) after expectant management of pre-eclampsia or intrauterine growth retardation (P value for interaction = 0.03). CONCLUSIONS: Multiple doses of antenatal steroids, especially dexamethasone, could influence the prevalence of persistent increases in brain parenchymal echogenicity in preterm infants.
Arsenio Spinillo; Alberto Chiara; Carola Bergante; Danila Biancheri; DePaoli Fabiana; Elisa Fazzi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  111     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  913-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, IRCCS Policlinico S. Matteo, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy.
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MeSH Terms
Brain Diseases / ultrasonography*
Epidemiologic Studies
Infant, Newborn
Infant, Premature, Diseases / ultrasonography*
Maternal Age
Maternal Exposure
Pregnancy Complications / etiology
Steroids / adverse effects
Reg. No./Substance:

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