Document Detail

Obstetric risk factors for early-onset schizophrenia in a Finnish birth cohort.
MedLine Citation:
PMID:  10784475     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Although case-control investigations have shown an association between obstetric complications and schizophrenia, particularly among patients with early onsets, cohort studies have mostly failed to confirm this effect. The authors examined whether a history of fetal hypoxia and other obstetric complications elevated risk for early-onset schizophrenia in a 1955 Helsinki birth cohort. METHOD: The subjects were 80 randomly selected patients with schizophrenia (36 with early and 44 with later onsets) representative of all available probands in the cohort, 61 of their nonschizophrenic siblings, and 56 demographically matched nonpsychiatric comparison subjects. Psychiatric diagnoses were obtained from structured clinical interviews, and obstetric data were taken from standardized, prospectively ascertained obstetric records. A score for hypoxia-associated obstetric complications was entered into logistic regression models, along with measures of prenatal infection and fetal growth retardation. RESULTS: Hypoxia-associated obstetric complications significantly increased the odds of early-onset schizophrenia but not of later-onset schizophrenia or unaffected sibling status, after prenatal infection and fetal growth retardation were taken into account. CONCLUSIONS: These findings support an association between obstetric complications and increased risk for early-onset schizophrenia. The authors advance a model whereby the neurotoxic effects of fetal hypoxia may lead to an early onset of schizophrenia due to premature cortical synaptic pruning.
I M Rosso; T D Cannon; T Huttunen; M O Huttunen; J Lönnqvist; T L Gasperoni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  157     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-17     Completed Date:  2000-05-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  801-7     Citation Subset:  AIM; IM    
Department of Psychology, University of Pennsylvania, Philadelphia, USA.
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MeSH Terms
Age of Onset
Asphyxia Neonatorum / epidemiology
Cohort Studies
Fetal Diseases / epidemiology*,  genetics
Fetal Growth Retardation / epidemiology
Fetal Hypoxia / epidemiology
Finland / epidemiology
Genetic Predisposition to Disease
Infant, Newborn
Logistic Models
Pregnancy Complications / epidemiology*
Risk Factors
Schizophrenia / epidemiology*,  genetics
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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