| Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes. | |
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MedLine Citation:
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PMID: 18579139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate obstetric outcomes with oocyte vitrification after ovarian stimulation (OS) and in vitro maturation (IVM) of immature oocytes. DESIGN: A prospective trial from October 2003 to April 2007. SETTING: University-based medical center. PATIENT(S): OS group: 38 patients undergoing intrauterine insemination who overresponded to OS. IVM group: 20 patients who had previous unsuccessful intrauterine insemination. INTERVENTION(S): Mature oocyte retrieval following OS. Immature oocyte retrieval and IVM. Oocyte vitrification, thawing, insemination, and transfer of the resulting embryos. MAIN OUTCOME MEASURE(S): Live-birth rates and obstetric outcomes. RESULT(S): The OS group was superior to the IVM group in terms of oocyte survival (81.4 +/- 22.6% vs. 67.5 +/- 26.1%), fertilization rate (75.6 +/- 22.5% vs. 64.2 +/- 19.9%), and cumulative embryo score (38.4 +/- 22.3 vs. 20.0 +/- 13.8). However, the differences in the implantation rate per embryo (19.1 +/- 25.8% vs. 9.6 +/- 24.1%), clinical pregnancy rate per cycle started (44.7%, vs. 20.0%), and live-birth rate per cycle started (39.5% vs. 20.0%) were not statistically significant. Twenty healthy babies were born in the OS group and four in the IVM group. CONCLUSION(S): Pregnancies achieved with vitrification of oocytes after OS and IVM treatments do not appear to be associated with adverse pregnancy outcomes. Vitrification of IVM oocytes represents a novel option for fertility preservation. |
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Authors:
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Ri-Cheng Chian; Jack Y J Huang; Lucy Gilbert; Weon-Young Son; Hananel Holzer; Shan Jin Cui; William M Buckett; Togas Tulandi; Seang Lin Tan |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-24 |
Journal Detail:
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Title: Fertility and sterility Volume: 91 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-07-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 2391-8 Citation Subset: IM |
Affiliation:
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McGill Reproductive Center, McGill University Health Centre, Montreal, Quebec, Canada. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Survival Cryopreservation / methods* Embryo Transfer / methods Female Fertilization Fertilization in Vitro / methods* Humans Infertility, Female / epidemiology Infertility, Male / epidemiology Male Oocyte Retrieval Oocytes / cytology, physiology* Organ Preservation / methods Pregnancy Pregnancy Outcome / epidemiology Prospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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