Document Detail

Obstetric outcomes following vitrification of in vitro and in vivo matured oocytes.
MedLine Citation:
PMID:  18579139     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate obstetric outcomes with oocyte vitrification after ovarian stimulation (OS) and in vitro maturation (IVM) of immature oocytes. DESIGN: A prospective trial from October 2003 to April 2007. SETTING: University-based medical center. PATIENT(S): OS group: 38 patients undergoing intrauterine insemination who overresponded to OS. IVM group: 20 patients who had previous unsuccessful intrauterine insemination. INTERVENTION(S): Mature oocyte retrieval following OS. Immature oocyte retrieval and IVM. Oocyte vitrification, thawing, insemination, and transfer of the resulting embryos. MAIN OUTCOME MEASURE(S): Live-birth rates and obstetric outcomes. RESULT(S): The OS group was superior to the IVM group in terms of oocyte survival (81.4 +/- 22.6% vs. 67.5 +/- 26.1%), fertilization rate (75.6 +/- 22.5% vs. 64.2 +/- 19.9%), and cumulative embryo score (38.4 +/- 22.3 vs. 20.0 +/- 13.8). However, the differences in the implantation rate per embryo (19.1 +/- 25.8% vs. 9.6 +/- 24.1%), clinical pregnancy rate per cycle started (44.7%, vs. 20.0%), and live-birth rate per cycle started (39.5% vs. 20.0%) were not statistically significant. Twenty healthy babies were born in the OS group and four in the IVM group. CONCLUSION(S): Pregnancies achieved with vitrification of oocytes after OS and IVM treatments do not appear to be associated with adverse pregnancy outcomes. Vitrification of IVM oocytes represents a novel option for fertility preservation.
Ri-Cheng Chian; Jack Y J Huang; Lucy Gilbert; Weon-Young Son; Hananel Holzer; Shan Jin Cui; William M Buckett; Togas Tulandi; Seang Lin Tan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-24
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2391-8     Citation Subset:  IM    
McGill Reproductive Center, McGill University Health Centre, Montreal, Quebec, Canada.
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MeSH Terms
Cell Survival
Cryopreservation / methods*
Embryo Transfer / methods
Fertilization in Vitro / methods*
Infertility, Female / epidemiology
Infertility, Male / epidemiology
Oocyte Retrieval
Oocytes / cytology,  physiology*
Organ Preservation / methods
Pregnancy Outcome / epidemiology
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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