Document Detail


Obstetric outcome of pregnancies following ICSI, classified according to sperm origin and quality.
MedLine Citation:
PMID:  10783376     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to report the outcome of all clinical pregnancies obtained after intracytoplasmic sperm injection (ICSI) performed during a 5 year period at two fertility clinics, with special reference to delivery outcome associated with different sperm origin and quality and the transfer of fresh or frozen-thawed pre-embryos. A total of 1293 clinical pregnancies was analysed. Deliveries occurred in 75.9% (n = 982) and early spontaneous abortion, late spontaneous abortion and ectopic pregnancy in 21.4, 1.0 and 1.2% respectively. Multiple birth occurred in 21.3% (208 sets of twins and one set of triplets) of the deliveries, with the highest incidence in the epididymal sperm group (30.2%) and lowest in the cryopreserved group (13.7%). A total of 1192 infants was born. Preterm birth occurred in 15.7% of all deliveries. Preterm birth was not related to sperm origin or quality but was related to multiple birth. The prematurity rate was 8.4%, 42.3% and 100% for singletons, twins and triplets respectively. Singleton infants born after cryopreservation as embryos had a significantly higher birthweight than the ejaculated sperm group with fresh embryo transfer. The perinatal mortality rate was 11.7 per 1000 born infants. Eighty-seven of the 1192 infants (7.3%) had a malformation, 40 of which were minor. The perinatal mortality rate and the malformation rate were similar in the different subgroups. Prenatal karyotyping was performed on 149 fetuses (12.5%) and abnormal results were found in four cases (2.7%). In conclusion, obstetric outcome of ICSI pregnancies was similar to that of conventional IVF and was not influenced by sperm origin or quality. The high incidence of multiple births is still the major concern.
Authors:
U B Wennerholm; C Bergh; L Hamberger; G Westlander; M Wikland; M Wood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  15     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-07-20     Completed Date:  2000-07-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1189-94     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / epidemiology
Abortion, Spontaneous / epidemiology
Adult
Birth Weight
Cohort Studies
Cryopreservation
Embryo, Mammalian / physiology
Female
Gestational Age
Humans
Incidence
Infant Mortality
Infant, Newborn
Infant, Premature
Karyotyping
Male
Pregnancy
Pregnancy Outcome*
Pregnancy, Multiple
Sperm Injections, Intracytoplasmic / methods*
Spermatozoa / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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