Document Detail

Obstetric and neonatal outcomes to recombinant porcine somatotropin administered in the last third of pregnancy to primiparous sows.
MedLine Citation:
PMID:  16731788     Owner:  NLM     Status:  MEDLINE    
This study aimed to investigate whether the administration of recombinant porcine somatotropin (rpST) late in gestation is associated with increased rates of obstetric and neonatal complications in primiparous sows. From days 80 to 114 of gestational age, 20 primiparous sows were randomly assigned to receive an intramuscular injection of either saline or 6 mg rpST/day. Throughout pregnancy, sows were fed 2.5 to 3 kg/day of a corn-soybean diet (14 MJ ME/kg). Of 111 piglets born to control sows and 109 piglets born to treated sows, 8.1% and 17.4% piglets respectively died intrapartum (P=0.04). Glucose blood levels in sows and live-born piglets in the rpST-treated group were significantly higher than in their corresponding controls. Birth weight of live-born piglets in the treated group was 1.4 +/- 0.1 kg versus 1.3 +/- 0.1 kg in the control group (P<0.0001). Birth weight of piglets born dead was also higher in the former than in the latter group (P<0.0001). No evidence of teratogenicity was observed in either of the groups. In conclusion, rpST administration in late pregnancy to primparous sows increased the rate of neonatal deaths and was associated with higher blood glucose levels in both sows and piglets.
María E Trujillo-Ortega; Daniel Mota-Rojas; Rafael Hernández-González; Elvia Yadira Velázquez-Armenta; Alejandro A Nava-Ocampo; Ramiro Ramírez-Necoechea; Marcelino Becerril-Herrera; María Alonso-Spilsbury
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  189     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-29     Completed Date:  2006-08-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  575-82     Citation Subset:  IM    
Department of Animal Production: Swine, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, México.
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MeSH Terms
Animals, Newborn / blood
Birth Weight / drug effects
Blood Glucose / analysis
Body Weight / drug effects
Fetal Death / chemically induced*
Gestational Age
Growth Hormone / adverse effects*
Hydrogen-Ion Concentration
Lactic Acid / blood
Organ Size / drug effects
Placenta / anatomy & histology
Pregnancy Complications / chemically induced*
Random Allocation
Swine / metabolism*
Reg. No./Substance:
0/Blood Glucose; 50-21-5/Lactic Acid; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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