Document Detail

Obstetric implications of the factor V leiden mutation: a review.
MedLine Citation:
PMID:  11857095     Owner:  NLM     Status:  MEDLINE    
Factor V Leiden (FVL) is a newly discovered genetic mutation that impairs one of the body's naturally occurring anticoagulation systems. The result is resistance to activated protein C and a predisposition to thrombosis. FVL is the most common cause of primary and recurrent venous thromboembolism in the pregnant and nonpregnant state. The FVL gene is common in the general population and transmitted in an autosomal dominant fashion. When FVL is combined with the prothrombotic state of pregnancy, the result is an increased propensity to manifest a number of pregnancy complications. These include recurrent pregnancy loss and stillbirth, severe and early-onset preeclampsia, placental abruption and possibly, intrauterine growth restriction. It remains unknown whether thromboprophylaxis is effective in ameliorating these pregnancy complications. The current literature and management recommendations are highlighted in this article.
Dena Bloomenthal; Marie-France Delisle; Francine Tessier; Peter Tsang
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of perinatology     Volume:  19     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-21     Completed Date:  2002-03-26     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  37-47     Citation Subset:  IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, University of British Columbia, Children's and Women's Health Centre of British Columbia, Vancouver, BC, Canada.
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MeSH Terms
Abortion, Habitual / etiology
Factor V / genetics*
Fetal Growth Retardation / etiology
Hypertension / etiology
Point Mutation*
Pregnancy Complications, Cardiovascular / etiology*,  physiopathology,  therapy
Protein C / physiology
Risk Factors
Venous Thrombosis / genetics*,  physiopathology,  therapy
Reg. No./Substance:
0/Protein C; 0/factor V Leiden; 9001-24-5/Factor V

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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