Document Detail

Obstetric complications and schizophrenia: a computed tomographic study.
MedLine Citation:
PMID:  3399585     Owner:  NLM     Status:  MEDLINE    
All patients aged 16-50 years who had been discharged from the Maudsley Hospital over a 4-year period with a diagnosis of schizophrenia were ascertained retrospectively. Case records were rated blindly for a history of obstetric complications (OCs). Sixty-one patients who satisfied the RDC for schizophrenia had undergone CT scanning. Those with a definite history of OCs presented at an earlier age. In this group widening of cortical sulci and fissures was more strongly correlated with VBR than in subjects without OCs. Moreover, large VBRs when accompanied by widened cortical sulci and fissures occurred more commonly in subjects with OCs than in those without. These results support the hypothesis that OCs, or a factor associated with them, lead to brain damage of aetiological significance in some cases of schizophrenia.
M J Owen; S W Lewis; R M Murray
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  18     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-09-01     Completed Date:  1988-09-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  331-9     Citation Subset:  IM    
Genetics Section, Institute of Psychiatry, London.
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MeSH Terms
Birth Injuries / pathology*
Brain / pathology
Brain Damage, Chronic / pathology
Cerebral Ventricles / pathology
Delirium, Dementia, Amnestic, Cognitive Disorders / pathology*
Middle Aged
Obstetric Labor Complications / pathology*
Prenatal Exposure Delayed Effects
Risk Factors
Schizophrenia / pathology*
Tomography, X-Ray Computed*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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