Document Detail

Obstetric complications in individuals diagnosed with autism and in healthy controls.
MedLine Citation:
PMID:  16324905     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to investigate birth complications in Israeli autistic probands. We interviewed 206 mothers of autistic probands and 152 healthy control mothers with a structured tool encompassing prenatal, perinatal, and neonatal complications. Analysis of obstetric suboptimality, derived by summing all positive items of each of the 3 categories and dividing them by the number of patients analyzed, revealed no prenatal between-group difference. The controls had a somewhat elevated perinatal suboptimality score, whereas the autistic probands had a significantly greater neonatal suboptimality score. These differences in obstetric suboptimality were retained after controlling for the demographic parameters found different between the 2 groups (sex of participants and mothers' years of schooling). Our findings suggest that the presence of nonspecific neonatal factors, rather than the specific influence of individual severe insults, may account for the elevated neonatal suboptimality found in probands diagnosed with autism compared with healthy controls.
Daniel Stein; Abraham Weizman; Aliza Ring; Yoram Barak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Comprehensive psychiatry     Volume:  47     ISSN:  0010-440X     ISO Abbreviation:  Compr Psychiatry     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-03-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372612     Medline TA:  Compr Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  69-75     Citation Subset:  IM    
Pediatric Psychosomatic Department, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel.
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MeSH Terms
Autistic Disorder / epidemiology,  etiology*
Case-Control Studies
Congenital Abnormalities / epidemiology
Infant, Newborn
Infant, Newborn, Diseases / epidemiology*
Israel / epidemiology
Multivariate Analysis
Obstetric Labor Complications / epidemiology*
Pregnancy Complications / epidemiology*

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