Document Detail

Obstetric complications in histories of monozygotic twins discordant and concordant for schizophrenia.
MedLine Citation:
PMID:  8178679     Owner:  NLM     Status:  MEDLINE    
Histories of obstetric complications (OCs) during pregnancy, labor-delivery and the neonatal period were investigated by detailed maternal report for 23 monozygotic (MZ) twin pairs discordant for schizophrenia, 10 MZ twin pairs concordant for schizophrenia and 7 normal MZ control pairs. Statistically significant differences in OC rates were found across these 3 groups. OCs being most frequent in discordant pairs and least frequent in normal control pairs. Labor complications were significantly more frequent in discordant than concordant pairs. OC rates were equivalent in sick and well discordant twins. The results provide evidence for the role of OCs in the development of schizophrenia, complications at the time of birth being especially associated with the development of schizophrenia in discordant twins.
T F McNeil; E Cantor-Graae; E F Torrey; K Sjöström; A Bowler; E Taylor; R Rawlings; E S Higgins
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta psychiatrica Scandinavica     Volume:  89     ISSN:  0001-690X     ISO Abbreviation:  Acta Psychiatr Scand     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-06-09     Completed Date:  1994-06-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370364     Medline TA:  Acta Psychiatr Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  196-204     Citation Subset:  IM    
Department of Psychiatry, Lund University, Malmõ, Sweden.
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MeSH Terms
Birth Weight / genetics
Diseases in Twins / genetics*,  psychology
Middle Aged
Obstetric Labor Complications / etiology*,  psychology
Risk Factors
Schizophrenia / diagnosis,  genetics*
Schizophrenic Psychology*
Social Environment
Twins, Monozygotic / genetics,  psychology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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