Document Detail

Obstetric complications in children born to parents with schizophrenia: a meta-analysis of case-control studies.
MedLine Citation:
PMID:  8685284     Owner:  NLM     Status:  MEDLINE    
On the basis of previous findings, we used meta-analyses to consider whether births to parents with schizophrenia have an increased risk of obstetric complications. Meta-analyses were based on published studies satisfying the following selection criteria. The schizophrenic diagnosis could apply to either parent: parents with non-schizophrenic psychoses were not included: only normal controls were accepted. In all, 14 studies provided effect sizes or data from which these could be derived. Studies were identified by data searches through MEDLINE, PSYCLIT and through references of papers relating to the subject. Births to individuals with schizophrenia incur an increased risk of pregnancy and birth complications, low birthweight and poor neonatal condition. However, in each case the effect size is small (mean r = 0.155; 95% CI = 0.057). The risk is greater for mothers with schizophrenia and is not confined to mothers with onset pre-delivery or to the births of the children who become schizophrenic themselves.
A Sacker; D J Done; T J Crow
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  26     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-08-19     Completed Date:  1996-08-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  279-87     Citation Subset:  IM    
Department of Psychiatry, University of Oxford.
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MeSH Terms
Brain Damage, Chronic / diagnosis*,  psychology
Child of Impaired Parents / psychology*
Delirium, Dementia, Amnestic, Cognitive Disorders / diagnosis*,  genetics,  psychology
Infant, Newborn
Obstetric Labor Complications / diagnosis*,  psychology
Pregnancy Outcome
Risk Factors
Schizophrenia / diagnosis*,  genetics
Schizophrenic Psychology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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