Document Detail

Obstetric complications in Marfan syndrome.
MedLine Citation:
PMID:  16236373     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the obstetric maternal and neonatal outcome of pregnancy in women with Marfan syndrome. METHODS: Retrospective observational multi-center study based on congenital heart disease registry. RESULTS: Sixty-three of the 122 enrolled women with Marfan syndrome had been pregnant 142 times (including 111 pregnancies>20 weeks, 28 (20%) miscarriages and 3 elective abortions). In 40% of all completed pregnancies an obstetric and/ or neonatal complication occurred. The most important complications were an increased percentage of premature deliveries (n=17, 15%) mainly due to preterm premature rupture of membranes and cervical incompetence and a markedly increased combined fetal and neonatal mortality of 7.1%. An obstetric and/or neonatal complication occurred in a similar proportion of pregnancies in women with a diagnosis of Marfan syndrome before pregnancy versus women with a diagnosis of Marfan syndrome after pregnancy (39% vs. 41%, p=0.85, respectively). CONCLUSION: In addition to cardiovascular complications, pregnancy in women with Marfan syndrome is associated with a high rate of premature deliveries, preterm premature rupture of membranes and increased mortality in the offspring.
Lilian J Meijboom; Willem Drenthen; Petronella G Pieper; Maarten Groenink; Joris A M van der Post; Janneke Timmermans; Adriaan A Voors; Jolien W Roos-Hesselink; Dirk J van Veldhuisen; Barbara J M Mulder;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-10-19
Journal Detail:
Title:  International journal of cardiology     Volume:  110     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-11-03     Revised Date:  2007-07-19    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  53-9     Citation Subset:  IM    
Department of Cardiology, Rm B2-240, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, and Department of Cardiology, Radboud Hospital Nijmegen, The Netherlands.
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MeSH Terms
Abortion, Spontaneous / etiology
Gestational Age
Marfan Syndrome / complications*,  ultrasonography
Middle Aged
Obstetric Labor, Premature
Pregnancy Complications*
Pregnancy Outcome*
Retrospective Studies
Ultrasonography, Prenatal

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