Document Detail

Obstetric antiphospholipid syndrome: an update on pathophysiology and management.
MedLine Citation:
PMID:  22161465     Owner:  NLM     Status:  In-Data-Review    
Antiphospholipid antibodies (aPLs) are acquired antibodies directed against negatively charged phospholipids, a group of inner and outer cell membrane antigens found in mammals. Obstetric antiphospholipid antibody syndrome (APS) is diagnosed in the presence of certain clinical features in conjunction with positive laboratory findings. Although obstetric APS was originally reported in association with slow progressive thrombosis and infarction in the placenta, it is most often associated with a poor obstetric outcome. In fact, obstetric APS is one of the most commonly identified causes of recurrent pregnancy loss (RPL). Thus obstetric APS is distinguished from APS in other organ systems where the most common manifestation is thrombosis. Several pathophysiological mechanisms of action of aPLs have been described. The most common histopathological finding in early pregnancy loss has been defective endovascular decidual trophoblastic invasion. Treatment with heparin and aspirin is emerging as the therapy of choice, with ∼75% of treated women with RPL and aPLs having a successful delivery compared with <50% without treatment. This review highlights the diagnostic challenges of obstetric APS, the obstetric complications associated with APS, proposed pathophysiological mechanisms of APS during pregnancy, and the management of women during and after pregnancy.
Joseph M Ernest; Paul B Marshburn; William H Kutteh
Related Documents :
494035 - Spontaneous rupture of the liver associated with pregnancy. a report of 5 cases.
7069775 - Behaviour of immune complexes and the complement system in normal pregnancy and pre-ecl...
10527265 - Interaction of the protein c/protein s anticoagulant system, the endothelium and pregna...
11095925 - Regulation of nitric oxide synthase activity by tetrahydrobiopterin in human placentae ...
10664625 - Comparison of disaturated phosphatidylcholine and fetal lung maturity surfactant/albumi...
12690765 - Major birth defects among infants with down syndrome in alexandria, egypt (1995-2000): ...
Publication Detail:
Type:  Journal Article     Date:  2011-12-08
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  29     ISSN:  1526-4564     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  522-39     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Department of Obstetrics and Gynecology, Carolinas Medical Center, Charlotte, North Carolina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Uterine anomaly and recurrent pregnancy loss.
Next Document:  Testing for inherited thrombophilia in recurrent miscarriage.