Document Detail

Observer variation in the measurement of Breslow depth and Clark's level in thin cutaneous malignant melanoma.
MedLine Citation:
PMID:  2013827     Owner:  NLM     Status:  MEDLINE    
We have assessed the degree of observer variation of both Breslow depth and Clark's level in a series of 50 thin malignant melanomas. Our findings are similar to those of previous international studies in the Breslow depth is the more reproducible measure. Significant intra- and inter-observer variation exists and in some cases it was up to +/- 0.86 mm. Even small differences will potentially affect patient management at our centre and this was analysed using kappa statistics. Good agreement was found between observers and this could be improved by comparing the mean of two or more measurements. This removes larger errors, but smaller observer errors and differences in subjective interpretation of the deepest malignant cell mean that agreement will never be more than 90 per cent. This is high compared with studies of observer variation in other pathological conditions, e.g., dysplasia of the cervix, but where surgical management is potentially disfiguring it is not high enough. We conclude that Breslow depth and Clark's level should not be the sole basis of wide excision protocols.
P S Colloby; K P West; A Fletcher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pathology     Volume:  163     ISSN:  0022-3417     ISO Abbreviation:  J. Pathol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-05-16     Completed Date:  1991-05-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0204634     Medline TA:  J Pathol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  245-50     Citation Subset:  IM    
Department of Pathology, Leicester Royal Infirmary, U.K.
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MeSH Terms
Biometry / methods
Histological Techniques
Melanoma / pathology*
Neoplasm Invasiveness
Neoplasm Staging
Observer Variation
Skin Neoplasms / pathology*
Comment In:
J Pathol. 1991 Nov;165(3):269-70   [PMID:  1762035 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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