Document Detail


Observer agreement in the grading of oral epithelial dysplasia.
MedLine Citation:
PMID:  12846853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine the extent of observer agreement in diagnosis of oral epithelial dysplasia (OED). Published studies of OED examiner agreement report relatively low agreement levels; however, these studies were limited by the methodologies employed. METHODS: For this study, 64 slides were each independently examined twice by three oral pathologists. Consistency was assessed by determining intra- and interexaminer agreement. Conformity was assessed by using the modal diagnosis as a gold standard. RESULTS: The group showed moderate interobserver agreement when grading the presence or absence of OED with a group-simple kappa (Ks) of 0.51 (95% CI = 0.42-0.61), and substantial agreement when using a 5-point ordinal scale with a group-weighted kappa (Kw) of 0.74 (95% CI = 0.64-0.85). The group showed fair to substantial intraexaminer agreement when assessing the presence or absence of OED, with Ks ranging from 0.22 to 0.78, and showing almost a perfect agreement using a 5-point ordinal scale, with Kw ranging from 0.82-0.96. Conformity with the comparison standard modal diagnosis was almost perfect, with pairwise Kw ranging from 0.81 to 0.92. CONCLUSION: Overall, there was substantial intra- and interobserver consistency and almost perfect conformity in the grading of OED. Appropriate statistical methods are necessary to determine the degree of observer agreement.
Authors:
D J Brothwell; D W Lewis; G Bradley; I Leong; R C K Jordan; D Mock; J L Leake
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Community dentistry and oral epidemiology     Volume:  31     ISSN:  0301-5661     ISO Abbreviation:  Community Dent Oral Epidemiol     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-08     Completed Date:  2003-10-20     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  0410263     Medline TA:  Community Dent Oral Epidemiol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  300-5     Citation Subset:  D; IM    
Affiliation:
Community Dentistry, Faculty of Dentistry, University of Manitoba, Manitoba, Canada. brothwel@ms.umanitoba.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma in Situ / diagnosis,  pathology
Carcinoma, Squamous Cell / diagnosis*,  pathology
Epithelium / pathology
Female
Humans
Male
Middle Aged
Mouth Mucosa / pathology
Mouth Neoplasms / diagnosis*,  pathology
Observer Variation
Precancerous Conditions / diagnosis*,  pathology
Reproducibility of Results

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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