| Observer variation in interpreting 18F-FDG PET/CT findings for lymphoma staging. | |
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MedLine Citation:
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PMID: 19759113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many studies demonstrate a high accuracy for PET in staging lymphoma, but few assess observer variation. This study quantified agreement for staging lymphoma with PET/CT. METHODS: The PET/CT images of 100 patients with lymphoma who had been referred for staging were reviewed by 3 experienced observers, with 2 observers reviewing each series a second time. Ann Arbor stage and individual nodal and extranodal regions were assessed. Weighted kappa (kappa(w)) and intraclass correlation coefficient were used to compare ratings. RESULTS: Intra- and interobserver agreement was high for Ann Arbor stage (kappa(w) = 0.79-0.91), number of nodal regions involved (intraclass correlation coefficient, 0.83-0.93), and presence of extranodal disease (kappa = 0.74-0.86). High agreement was also observed for all nodal regions (kappa(w) > 0.60) except hilar (kappa(w) = 0.56-0.82) and infraclavicular (kappa(w) = 0.14-0.55). Lower agreement was observed for bowel involvement (kappa(w) = 0.37-0.71). CONCLUSION: Experienced observers had a high level of agreement using PET/CT for lymphoma staging, supporting its use as a robust noninvasive staging tool. Further research is needed to evaluate observer variability for restaging during and after chemotherapy. |
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Authors:
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Michael S Hofman; Nigel C Smeeton; Sheila C Rankin; Tom Nunan; Michael J O'Doherty |
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Publication Detail:
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Type: Journal Article Date: 2009-09-16 |
Journal Detail:
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Title: Journal of nuclear medicine : official publication, Society of Nuclear Medicine Volume: 50 ISSN: 1535-5667 ISO Abbreviation: J. Nucl. Med. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-01 Completed Date: 2009-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0217410 Medline TA: J Nucl Med Country: United States |
Other Details:
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Languages: eng Pagination: 1594-7 Citation Subset: IM |
Affiliation:
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PET Imaging Centre, Kings College London, London, United Kingdom. nucmedpet@drhofman.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Fluorodeoxyglucose F18 / diagnostic use* Humans Image Interpretation, Computer-Assisted / methods* Lymphoma / diagnosis*, pathology*, radiography, radionuclide imaging Middle Aged Neoplasm Staging Observer Variation Positron-Emission Tomography* Tomography, X-Ray Computed Young Adult |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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