| Observations of ventilation during resuscitation in a canine model. | |
| | |
MedLine Citation:
|
PMID: 7994856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Fear of infection limits the willingness of laymen to do cardiopulmonary resuscitation (CPR). This study assessed the time course of change in arterial blood gases during resuscitation with only chest compression (no ventilation) in an effort to identify the time for which ventilation could be deferred. METHODS AND RESULTS: Aortic pressures and arterial blood gases were monitored in seven 20- to 30-kg dogs in ventricular fibrillation (VF) at 2-minute intervals during chest compression alone (no ventilation) at 80 to 100 compressions per minute. Before the induction of ventricular fibrillation, all animals were intubated and ventilated with room air, 10 mL/kg. The endotracheal tube was removed when VF was induced. Pre-VF arterial pH, PCO2, and O2 saturation were (mean +/- SEM) 7.39 +/- 0.02, 27.0 +/- 1.5 mm Hg, and 97.5 +/- 0.5%, respectively, with aortic pressures being 143.2 +/- 5.7/116.2 +/- 4.6 mm Hg. At 4 minutes of chest compression alone, the corresponding values were 7.39 +/- 0.03, 24.3 +/- 3.1 mm Hg, and 93.9 +/- 3.0%, with an arterial pressure of 48.1 +/- 7.7/22.6 +/- 3.9 mm Hg. Mean minute ventilation during the fourth minute of CPR, measured with a face mask-pneumotachometer, was 5.2 +/- 1.1 L/min. CONCLUSIONS: These data suggest that in the dog model of witnessed arrest, chest compression alone during CPR can maintain adequate gas exchange to sustain O2 saturation > 90% for > 4 minutes. The need for immediate ventilation during witnessed arrest should be reexamined. |
| | |
Authors:
|
N C Chandra; K G Gruben; J E Tsitlik; R Brower; A D Guerci; H H Halperin; M L Weisfeldt; S Permutt |
Related Documents
:
|
7400006 - Augmented diffusion in the airways can support pulmonary gas exchange. 10023276 - The cuffed oropharyngeal airway for spontaneous ventilation anaesthesia. clinical appra... 16798556 - Laryngeal function and nasal ventilatory support in the neonatal period. 863816 - Frequency dependence of ventilation distribution in normal and obstructed lungs. 2347916 - Acute effects of mildly intoxicating levels of alcohol on left ventricular function in ... 8853336 - Brain angiotensin ii tonically modulates sympathetic baroreflex in rabbit ventrolateral... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Circulation Volume: 90 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1994 Dec |
Date Detail:
|
Created Date: 1995-01-17 Completed Date: 1995-01-17 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 3070-5 Citation Subset: AIM; IM |
Affiliation:
|
Peter Belfer Laboratory for Myocardial Research, Department of Medicine, Johns Hopkins Medical Institutions, Baltimore, MD. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Arteries Cardiopulmonary Resuscitation* / methods Dogs Hydrogen-Ion Concentration Oxygen / blood Partial Pressure Pressure Respiration* Thorax Time Factors |
| Grant Support | |
ID/Acronym/Agency:
|
5P50-HL-17655/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of ventilation on resuscitation in an animal model of cardiac arrest.
Next Document: Effect of myocardial fiber direction on epicardial potentials.