| Observations on some cardiopulmonary effects of midazolam, xylazine and a midazolam/ketamine combination in the goat. | |
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MedLine Citation:
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PMID: 10852682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Xylazine, midazolam and a midazolam/ketamine combination were administered to 6 goats in a randomised 3-way block design. All goats received all treatments with at least a 7-day interval between treatments. Statistically significant (P < 0.05) changes were observed in some of the measured cardiopulmonary variables for xylazine and midazolam/ ketamine. Xylazine administration resulted in statistically significant decreases in minute volume, arterial partial pressure of oxygen, heart rate and mean arterial blood pressure. The increase in arterial partial pressure of carbon dioxide was not statistically significant. For the midazolam/ketamine combination, the decrease in tidal volume was statistically significant, but not the decrease in minute volume and increase in arterial partial pressure of carbon dioxide. The decrease in the arterial partial pressure of oxygen was also statistically significant. The mean arterial blood pressure for the combination was statistically significantly higher compared to xylazine. The changes in cardiopulmonary variables after midazolam administration were not statistically significant, such as tidal and minute volume, arterial partial pressure of oxygen and carbon dioxide. However, clinically significant effects such as hypoventilation and hypoxia were observed after its administration. The change in mean arterial blood pressure was minimal. |
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Authors:
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G F Stegmann |
Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the South African Veterinary Association Volume: 70 ISSN: 1019-9128 ISO Abbreviation: J S Afr Vet Assoc Publication Date: 1999 Sep |
Date Detail:
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Created Date: 2000-07-31 Completed Date: 2000-07-31 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7503122 Medline TA: J S Afr Vet Assoc Country: SOUTH AFRICA |
Other Details:
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Languages: eng Pagination: 122-6 Citation Subset: IM |
Affiliation:
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Department of Companion Animal Surgery, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Anesthesia
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pharmacology Analgesics / pharmacology* Anesthetics, Intravenous / pharmacology* Animals Blood Gas Analysis / veterinary Blood Pressure Determination / veterinary Cardiovascular Physiological Phenomena / drug effects* Data Interpretation, Statistical Goats* / blood Hypnotics and Sedatives / pharmacology Ketamine / pharmacology Male Midazolam / pharmacology Pulmonary Ventilation / drug effects* Xylazine / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Anesthesia; 0/Analgesics; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 59467-70-8/Midazolam; 6740-88-1/Ketamine; 7361-61-7/Xylazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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