Document Detail

Observations on some cardiopulmonary effects of midazolam, xylazine and a midazolam/ketamine combination in the goat.
MedLine Citation:
PMID:  10852682     Owner:  NLM     Status:  MEDLINE    
Xylazine, midazolam and a midazolam/ketamine combination were administered to 6 goats in a randomised 3-way block design. All goats received all treatments with at least a 7-day interval between treatments. Statistically significant (P < 0.05) changes were observed in some of the measured cardiopulmonary variables for xylazine and midazolam/ ketamine. Xylazine administration resulted in statistically significant decreases in minute volume, arterial partial pressure of oxygen, heart rate and mean arterial blood pressure. The increase in arterial partial pressure of carbon dioxide was not statistically significant. For the midazolam/ketamine combination, the decrease in tidal volume was statistically significant, but not the decrease in minute volume and increase in arterial partial pressure of carbon dioxide. The decrease in the arterial partial pressure of oxygen was also statistically significant. The mean arterial blood pressure for the combination was statistically significantly higher compared to xylazine. The changes in cardiopulmonary variables after midazolam administration were not statistically significant, such as tidal and minute volume, arterial partial pressure of oxygen and carbon dioxide. However, clinically significant effects such as hypoventilation and hypoxia were observed after its administration. The change in mean arterial blood pressure was minimal.
G F Stegmann
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the South African Veterinary Association     Volume:  70     ISSN:  1019-9128     ISO Abbreviation:  J S Afr Vet Assoc     Publication Date:  1999 Sep 
Date Detail:
Created Date:  2000-07-31     Completed Date:  2000-07-31     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7503122     Medline TA:  J S Afr Vet Assoc     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  122-6     Citation Subset:  IM    
Department of Companion Animal Surgery, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
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MeSH Terms
Adjuvants, Anesthesia / pharmacology
Analgesics / pharmacology*
Anesthetics, Intravenous / pharmacology*
Blood Gas Analysis / veterinary
Blood Pressure Determination / veterinary
Cardiovascular Physiological Phenomena / drug effects*
Data Interpretation, Statistical
Goats* / blood
Hypnotics and Sedatives / pharmacology
Ketamine / pharmacology
Midazolam / pharmacology
Pulmonary Ventilation / drug effects*
Xylazine / pharmacology
Reg. No./Substance:
0/Adjuvants, Anesthesia; 0/Analgesics; 0/Anesthetics, Intravenous; 0/Hypnotics and Sedatives; 59467-70-8/Midazolam; 6740-88-1/Ketamine; 7361-61-7/Xylazine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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