| Observations on praziquantel against Schistosoma haematobium. | |
| | |
MedLine Citation:
|
PMID: 7195249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
1. 2-Cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinolin-4-one (praziquantel, EMBAY 8440, Biltricide) in single oral doses between 15 and 50 mg/kg given to subjects of all ages with Schistosoma haematobium infections produced few side effects even at the higher doses. Parasitological results were as follows: a) 15--20 mg/kg were too low to consistently give a favourable parasitological response. b) 21--25 mg/kg cured a high proportion of cases but because of poor response in some persons with high pretreatment egg loads, this dose range is not recommended. c) Doses of 45--50 mg/kg did not appear to improve efficacy when compared with 30--40 mg/kg. 2. Praziquantel was highly effective and had low toxicity in a controlled trial in schoolchildren. There was no significant difference in efficacy between two single dose regimens (30 and 40 mg/kg) and a split dose of 2x20 mg/kg given 4 h apart. In long-term follow-up examination no viable eggs were being excreted in 45 of 53 (84.9%) and 37 of 50 (74%) subjects examined 1 and 2 years, respectively, after treatment. 3. 16 persons excreting viable eggs 6 months after treatment were retreated with 35 mg/kg. Six months later 14 of the 16 (87.5%) were cured. |
| | |
Authors:
|
J E McMahon |
Related Documents
:
|
15597709 - Effect of artemether on schistosoma mansoni: dose-efficacy relationship, and changes in... 6118029 - The long term effects of repeated diethylcarbamazine administration with special refere... 10870669 - Study of immunological and virological parameters during thalidomide treatment of siv-i... 1878259 - Potentials of shigella flexneri y strain tsf21 as a candidate vaccine against shigellos... 8369939 - Prophylactic use of cefuroxime in biliary tract surgery: randomized controlled trial of... 2167039 - In vitro and in vivo evidence that the antiviral activity of 2',3'-dideoxycytidine is t... 20165849 - A phase i study of obatoclax mesylate, a bcl-2 antagonist, plus topotecan in solid tumo... 23659169 - A new flavonoid c-glycoside from solanum elaeagnifolium with hepatoprotective and curat... 14675099 - Safety of plasmin in the setting of concomitant aspirin and heparin administration in a... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Arzneimittel-Forschung Volume: 31 ISSN: 0004-4172 ISO Abbreviation: Arzneimittelforschung Publication Date: 1981 |
Date Detail:
|
Created Date: 1981-07-20 Completed Date: 1981-07-20 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372660 Medline TA: Arzneimittelforschung Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 579-80 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Child Humans Isoquinolines / therapeutic use* Praziquantel / adverse effects, therapeutic use* Schistosoma haematobium Schistosomiasis / drug therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Isoquinolines; 55268-74-1/Praziquantel |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Trial of praziquantel in the treatment of urinary schistosomiasis in Senegal
Next Document: Epidemiological study of foci of S. intercalatum schistosomiasis in Eseka and Edea (Cameroon). Effec...