Document Detail

Observations on neutropenia associated with haemodialysis.
MedLine Citation:
PMID:  5823050     Owner:  NLM     Status:  MEDLINE    
In the first 30 minutes of haemodialysis, in patients with chronic renal failure, there is a dramatic fall in total neutrophil count in the peripheral blood. An hour after the start of dialysis this has returned to normal.We have carried out a series of experiments in an attempt to elucidate the cause of this neutropenia. Both the patient and the membranes of the dialyser appeared to be a necessary combination to produce these changes, which could not be induced by the infusion of blood or saline that had previously been in contact with the dialyser. The composition of the dialysing fluid was not related to the fall of white count, and this fall was repeated when the patient was connected to a second dialyser after recovering from the neutropenia caused by the first. It was only when reusing a kidney, by rinsing it out and resterilizing it, that the neutropenia could be modified, but this was not a constant finding.
E K Smith; K Jobbins
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  4     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1969 Oct 
Date Detail:
Created Date:  1969-11-27     Completed Date:  1969-11-27     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  70-3     Citation Subset:  AIM; IM    
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MeSH Terms
Agranulocytosis / etiology*
Isotonic Solutions
Leukocyte Count
Membranes, Artificial
Renal Dialysis*
Time Factors
Reg. No./Substance:
0/Isotonic Solutions; 0/Membranes, Artificial

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