| Observations on the effects of aerosolized albuterol in acute asthma. | |
| | |
MedLine Citation:
|
PMID: 9032178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To determine the dose of albuterol required to terminate acute episodes of asthma, 92 acutely ill subjects received three doses of 2.5 mg each by nebulization every 20 min. Peak expiratory flow rates (PEFR) and signs and symptoms were serially monitored. A dose-response increase in pulmonary function was found, but only 66% of the subjects improved sufficiently to be sent home. Of these, 56% required < or = 5.0 mg of drug to reach the discharge threshold, whereas the remainder needed 7.5 mg. In 34% of participants, albuterol was ineffectual. These individuals were characterized by more severe obstruction at presentation, and after three doses of medication their PEFR still did not exceed 40% of the expected value. Further treatment in the emergency department (ED) or hospital was not immediately helpful, and these patients ultimately required 3.8 +/- 0.4 d of inpatient care to become asymptomatic. There were no discernible differences between responders and nonresponders in the type or quantity of medications used. However, the nonresponders had more severe disease as measured by recurrent hospitalizations and ED visits. This study demonstrates that, in emergency situations, albuterol does not relieve acute airway obstruction in all asthmatic individuals with equal efficacy. Two-thirds of patients are sensitive, and in these patients 5 to 7.5 mg of albuterol provides optimal treatment. In the remainder, albuterol, even in high doses, has little effect for days. |
| | |
Authors:
|
L Strauss; R Hejal; G Galan; L Dixon; E R McFadden |
Related Documents
:
|
9426088 - Annual variability in methacholine responsiveness in nonasthmatic working adults. 9759798 - A 3-month comparison of formoterol with terbutaline via turbuhaler. a placebo-controlle... 21952398 - Comparison of behavioral effects of morphine and fentanyl in dogs and cats. 12464938 - Effect of beta-adrenergic agonists on mucociliary clearance. 17383998 - The retinal tolerance to bevacizumab in co-application with a recombinant tissue plasmi... 18827368 - High dosage sildenafil induces hearing impairment in mice. |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: American journal of respiratory and critical care medicine Volume: 155 ISSN: 1073-449X ISO Abbreviation: Am. J. Respir. Crit. Care Med. Publication Date: 1997 Feb |
Date Detail:
|
Created Date: 1997-03-11 Completed Date: 1997-03-11 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 454-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Emergency Medicine, University Hospitals, Cleveland, Ohio 44106-5067, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Adolescent Adult Aerosols / administration & dosage Albuterol / administration & dosage, therapeutic use* Asthma / drug therapy*, physiopathology Bronchodilator Agents / administration & dosage, therapeutic use* Dose-Response Relationship, Drug Emergencies Female Humans Male Middle Aged Peak Expiratory Flow Rate |
| Grant Support | |
ID/Acronym/Agency:
|
HL-37117/HL/NHLBI NIH HHS; M01 RR00080/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Aerosols; 0/Bronchodilator Agents; 18559-94-9/Albuterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Granulocyte activation markers in induced sputum: comparison between chronic obstructive pulmonary d...
Next Document: Airway anesthesia and respiratory adaptations to dead space loading and exercise.