Document Detail

Observations on degenerative changes within the optic nerve in patients with primary open glaucoma and arterial hypertension: 6-month follow-up.
MedLine Citation:
PMID:  23031148     Owner:  NLM     Status:  In-Data-Review    
J Clin Hypertens (Greenwich). 2012;14:701-710. ©2012 Wiley Periodicals, Inc. The authors aimed to determine the effect of the time of hypotensive drug administration on the progress of degenerative changes within the optic nerve in patients with hypertension and glaucoma. Two groups were included in the study: group A comprised patients-dippers taking drugs in the mornings, and group B comprised patients-nondippers taking drugs both in the mornings and in the evenings. After 6 months, group B showed significant drops in nocturnal diastolic blood pressure (BP) (month 1=73.27 mm Hg vs month 6=67.50 mm Hg), nocturnal mean BP (89.34 vs 84.65 mm Hg), and minimum diastolic BP (50.74 vs 44.03 mm Hg). Group B also showed significant reductions in nocturnal ocular perfusion pressure (43.0 vs 39.73), retinal nerve fiber layer thickness (131.31 vs 113.12 μm), and flow in the eye vessels. Taking hypotensive drugs in the evening may significantly decrease blood flow in the eye arteries, cause degenerative changes within the optic nerves, and result in greater loss in the field of vision.
Beata Krasińska; Maciej Banach; Małgorzata Karolczak-Kulesza; Zbigniew Krasiński; Jerzy Głuszek; Andrzej Tykarski
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Publication Detail:
Type:  Journal Article     Date:  2012-08-13
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  14     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  701-10     Citation Subset:  IM    
Copyright Information:
© 2012 Wiley Periodicals, Inc.
From the Department of Hypertension and Vascular and Internal Diseases, University of Medical Sciences, Poznan;the Department of Hypertension, Medical University of Lodz, Lodz;the Department of Ophthalmologythe Department of General and Vascular Surgery, University of Medical Sciences, Poznan, Poland.
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