Document Detail

Observational study on the stability of the psychological status during normal pregnancy and increased blood levels of neuroactive steroids with GABA-A receptor agonist activity.
MedLine Citation:
PMID:  16406349     Owner:  NLM     Status:  MEDLINE    
We investigated whether pregnancy could modify psychological symptoms and whether neuroactive steroids which exert an anti-anxiety effect by acting on the gamma-aminobutyric acid (GABA)-A receptors, are modified during pregnancy in young healthy women. Healthy volunteer women in the Department of Obstetrics and Gynecology at Cagliari University participated in the study. They were divided into women with low (group 1, seven subjects) and high (group 2, seven subjects) psychological score by SCL-90 psychometric scale. Age, body mass index and physiological status of pregnancy did not differ between the groups. The subjects were studied before pregnancy during the follicular phase (FP), and the luteal phase (LP) of the menstrual cycle (MC) and four times during pregnancy (at 14th, 22nd, 30th, and 38th week). SCL-90 psychometric scale, circulating levels of progesterone (P4), 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone, AP), 3alpha,21-dihydroxy-5alpha-pregnan-20-one (allotetrahydrodeoxy-corticosterone, THDOC), cortisol and DHEAS were assayed at each visit. The SCL-90 global score and the intensity of psychological symptoms differ between the groups, but within each group they did not change both during MC and during pregnancy. The DHEAS and cortisol levels did not differ between the groups. DHEAS did not change during the study, whereas cortisol levels increased during pregnancy in both groups. Progesterone, AP, and THDOC levels were higher during LP than during FP and further increased during pregnancy, without any difference between the groups. In conclusion, pregnancy does not seem to interfere with the psychological status of healthy women independently of the psychological basal score. Some neuroactive steroids with anxiolytic activity seem to increase during pregnancy depending on placental function. Their increase could represent some kind of protection against maternal anxiety and stress due to concerns about the pregnancy outcome.
Anna Maria Paoletti; Sandra Romagnino; Rossana Contu; Marisa Margherita Orrù; Maria Francesca Marotto; Pierina Zedda; Stefano Lello; Giovanni Biggio; Alessandra Concas; Gian Benedetto Melis
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-01-06
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  31     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  England    
Other Details:
Languages:  eng     Pagination:  485-92     Citation Subset:  IM    
Dipartimento Chirurgico Materno Infantile e di Scienze delle Immagini, Sezione di Clinica Ginecologica Ostetrica e di Fisiopatologia della Riproduzione Umana, Università di Cagliari, Via Ospedale 46, I-09124 Cagliari, Italy.
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MeSH Terms
Dehydroepiandrosterone Sulfate / blood
Desoxycorticosterone / analogs & derivatives,  blood
Follow-Up Studies
Hydrocortisone / blood
Menstrual Cycle / blood,  psychology*
Neuropsychological Tests
Pregnancy / blood,  psychology*
Pregnanes / blood*
Pregnanolone / blood
Progesterone / blood
Prospective Studies
Psychiatric Status Rating Scales
Receptors, GABA-A / agonists*,  metabolism
Reference Values
Stress, Psychological / blood*
Reg. No./Substance:
0/Pregnanes; 0/Receptors, GABA-A; 128-20-1/Pregnanolone; 50-23-7/Hydrocortisone; 567-03-3/tetrahydrodeoxycorticosterone; 57-83-0/Progesterone; 64-85-7/Desoxycorticosterone; 651-48-9/Dehydroepiandrosterone Sulfate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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