Document Detail

Observational study of blue dye-assisted four-node sampling for axillary staging in early breast cancer.
MedLine Citation:
PMID:  20609549     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The use of radioisotopes (RIs) is regulated and not all institutions have nuclear medicine facilities for sentinel node biopsy (SNB). We previously reported blue dye-assisted four-node axillary sampling (4NAS/dye) to be a suitable method for detecting sentinel nodes (SNs) without RIs. Here, we present an interim report on an observational study of this technique. METHODS: From May 2003 to June 2008, 234 early breast cancer patients underwent SNB with 4NAS/dye. Lymphatic mapping was performed by injection of patent blue, and axillary sampling was performed until 4 SNs were detected. Patients with metastatic SNs underwent axillary lymph node dissection (ALND) at levels I and II, while SN-negative patients did not undergo further axillary procedures. RESULTS: The SN identification rate was 99%. In total, 44 patients were diagnosed with metastatic disease by using the 4NAS/dye technique and underwent ALND; the remaining 189 patients did not undergo ALND (the SNB group). After a median follow-up period of 54 months, only 1 patient (0.5%) in the SNB group developed axillary recurrence. For the 4NAS/dye procedure, blue SNs were harvested in 220 patients (94%) and only unstained SNs were harvested in 13 patients (6%). Among the 44 patients with SN metastases, foci were found in blue SNs in 37 patients (84%), while they were found in only unstained SNs in 7 patients (16%). CONCLUSIONS: SNB with 4NAS/dye is a safe and reliable technique for treatment of early breast cancer patients. This technique may be particularly useful for surgeons who do not have access to radioisotope facilities.
K Narui; T Ishikawa; A Kito; D Shimizu; T Chishima; N Momiyama; Y Ichikawa; T Sasaki; A Nozawa; Y Inayama; H Shimada; I Endo
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Publication Detail:
Type:  Journal Article     Date:  2010-07-07
Journal Detail:
Title:  European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology     Volume:  36     ISSN:  1532-2157     ISO Abbreviation:  Eur J Surg Oncol     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504356     Medline TA:  Eur J Surg Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  731-6     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010. Published by Elsevier Ltd.
Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan.
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MeSH Terms
Breast Neoplasms / drug therapy,  pathology*,  surgery*
Chemotherapy, Adjuvant
Coloring Agents / diagnostic use
Lymph Nodes / pathology*,  surgery*
Lymphatic Metastasis / diagnosis
Middle Aged
Neoplasm Staging
Rosaniline Dyes / diagnostic use*
Sentinel Lymph Node Biopsy / methods*
Reg. No./Substance:
0/Coloring Agents; 0/Rosaniline Dyes; 129-17-9/patent blue violet

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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