| Observational study of blue dye-assisted four-node sampling for axillary staging in early breast cancer. | |
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MedLine Citation:
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PMID: 20609549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The use of radioisotopes (RIs) is regulated and not all institutions have nuclear medicine facilities for sentinel node biopsy (SNB). We previously reported blue dye-assisted four-node axillary sampling (4NAS/dye) to be a suitable method for detecting sentinel nodes (SNs) without RIs. Here, we present an interim report on an observational study of this technique. METHODS: From May 2003 to June 2008, 234 early breast cancer patients underwent SNB with 4NAS/dye. Lymphatic mapping was performed by injection of patent blue, and axillary sampling was performed until 4 SNs were detected. Patients with metastatic SNs underwent axillary lymph node dissection (ALND) at levels I and II, while SN-negative patients did not undergo further axillary procedures. RESULTS: The SN identification rate was 99%. In total, 44 patients were diagnosed with metastatic disease by using the 4NAS/dye technique and underwent ALND; the remaining 189 patients did not undergo ALND (the SNB group). After a median follow-up period of 54 months, only 1 patient (0.5%) in the SNB group developed axillary recurrence. For the 4NAS/dye procedure, blue SNs were harvested in 220 patients (94%) and only unstained SNs were harvested in 13 patients (6%). Among the 44 patients with SN metastases, foci were found in blue SNs in 37 patients (84%), while they were found in only unstained SNs in 7 patients (16%). CONCLUSIONS: SNB with 4NAS/dye is a safe and reliable technique for treatment of early breast cancer patients. This technique may be particularly useful for surgeons who do not have access to radioisotope facilities. |
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Authors:
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K Narui; T Ishikawa; A Kito; D Shimizu; T Chishima; N Momiyama; Y Ichikawa; T Sasaki; A Nozawa; Y Inayama; H Shimada; I Endo |
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Publication Detail:
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Type: Journal Article Date: 2010-07-07 |
Journal Detail:
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Title: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology Volume: 36 ISSN: 1532-2157 ISO Abbreviation: Eur J Surg Oncol Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-19 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8504356 Medline TA: Eur J Surg Oncol Country: England |
Other Details:
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Languages: eng Pagination: 731-6 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010. Published by Elsevier Ltd. |
Affiliation:
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Department of Breast and Thyroid Surgery, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Axilla Breast Neoplasms / drug therapy, pathology*, surgery* Chemotherapy, Adjuvant Coloring Agents / diagnostic use Female Humans Lymph Nodes / pathology*, surgery* Lymphatic Metastasis / diagnosis Middle Aged Neoplasm Staging Rosaniline Dyes / diagnostic use* Sentinel Lymph Node Biopsy / methods* |
| Chemical | |
Reg. No./Substance:
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0/Coloring Agents; 0/Rosaniline Dyes; 129-17-9/patent blue violet |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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