Document Detail

An observational study of early neonatal biochemical parameters in twins.
MedLine Citation:
PMID:  20700863     Owner:  NLM     Status:  In-Data-Review    
Early neonatal biochemical values are generally considered to reflect maternal values. However, studies have been inconclusive due to the statistical methods used. We hypothesized that there would not be important differences in plasma biochemistry between newborn twins, suggesting a common mechanism of control, and that differences between unrelated infant pairs would be greater. All twins over a 5-year period who had plasma biochemistry measured within 6 hours of birth were identified retrospectively. An unrelated control infant was matched to one of each twin pair. The 95% limits of agreement for plasma urea, creatinine, and sodium were calculated for twin pairs and unrelated matched infant pairs. Fifty-three twin pairs were studied. For urea, creatinine, and sodium, 95% of differences between twins were less than or equal to 1.5 mmol/L (8.9 mg/dL), 9.2 μmol/L (0.1 mg/dL), and 5.1 mmol/L (11.7 mg/dL), respectively. In unrelated infant pairs, the corresponding values were 4.0 mmol/L (24.3 mg/dL), 33.9 μmol/L (0.4 mg/dL), and 8.2 mmol/L (18.9 mg/dL). Differences between unrelated infant pairs were significantly wider than differences between twins ( P < 0.001). This study has demonstrated a close and significant agreement in urea, sodium, and creatinine when measured soon after birth in twin pairs compared with unrelated infants, implying a common mechanism of control.
Paul Henderson; David Cordiner; Ben Stenson
Related Documents :
2880763 - Twin birth weight discordancy in nigeria.
6252883 - Factors contributing to postweaning diarrhoea in a large intensive piggery.
14500903 - Newborn infants can organize the auditory world.
Publication Detail:
Type:  Journal Article     Date:  2010-08-10
Journal Detail:
Title:  American journal of perinatology     Volume:  28     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Neonatal Unit, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Clinical course of symptomatic spontaneous pneumothorax in term and late preterm newborns: report fr...
Next Document:  Endothelin-1 and L-arginine in preterm infants with respiratory distress.