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An observational study of early neonatal biochemical parameters in twins.
MedLine Citation:
PMID:  20700863     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Early neonatal biochemical values are generally considered to reflect maternal values. However, studies have been inconclusive due to the statistical methods used. We hypothesized that there would not be important differences in plasma biochemistry between newborn twins, suggesting a common mechanism of control, and that differences between unrelated infant pairs would be greater. All twins over a 5-year period who had plasma biochemistry measured within 6 hours of birth were identified retrospectively. An unrelated control infant was matched to one of each twin pair. The 95% limits of agreement for plasma urea, creatinine, and sodium were calculated for twin pairs and unrelated matched infant pairs. Fifty-three twin pairs were studied. For urea, creatinine, and sodium, 95% of differences between twins were less than or equal to 1.5 mmol/L (8.9 mg/dL), 9.2 μmol/L (0.1 mg/dL), and 5.1 mmol/L (11.7 mg/dL), respectively. In unrelated infant pairs, the corresponding values were 4.0 mmol/L (24.3 mg/dL), 33.9 μmol/L (0.4 mg/dL), and 8.2 mmol/L (18.9 mg/dL). Differences between unrelated infant pairs were significantly wider than differences between twins ( P < 0.001). This study has demonstrated a close and significant agreement in urea, sodium, and creatinine when measured soon after birth in twin pairs compared with unrelated infants, implying a common mechanism of control.
Authors:
Paul Henderson; David Cordiner; Ben Stenson
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Publication Detail:
Type:  Journal Article     Date:  2010-08-10
Journal Detail:
Title:  American journal of perinatology     Volume:  28     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  111-6     Citation Subset:  IM    
Copyright Information:
© Thieme Medical Publishers.
Affiliation:
Neonatal Unit, Simpson Centre for Reproductive Health, Royal Infirmary of Edinburgh, Edinburgh, UK.
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