Document Detail

Observation of persistent fundus fluorescence after internal limiting membrane peeling assisted by indocyanine green solution of different concentrations.
MedLine Citation:
PMID:  21425495     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: To investigate how long indocyanine green (ICG) remains in the fundus after vitreoretinal surgery assisted with ICG, and to identify factors that influence the persistence duration.
METHODS: Fifty five eyes diagnosed as idiopathic macular hole (Stage 2 and 3) were randomly divided into five groups. ICG solution at concentrations of 5, 2.5, 2.5, 1.25, and 0.5 mg/ml, employed in cases of Group I to V respectively, was applied to stain the internal limiting membrane (ILM) during the procedure of internal limiting membrane peeling. A prospective study was carried out after pars plana vitrectomy and ILM peeling were performed on 55 eyes with Stage 2, 3, or 4 idiopathic macular holes. Infrared fundus pictures were obtained in all patients before and after surgery.
RESULTS: High levels of fluorescence from residual ICG (ICG hyperfluorescence) were mainly localized at the posterior pole of the fundus after surgery. In Group Ⅰ, Ⅱ, III, IV and V, the duration of persistence of flurorescence from ICG was 8.330.87, 3.590.94, 3.750.79, 2.300.48, and 1.290.49 months, respectively. Although no significant difference was detected between Group Ⅱ and Group III, the general inter-group difference was significant among the five groups in which different ICG concentration was applied. In Group III, even though 90% of the macular holes acquired anatomical closure, ICG hyperfluorescence was detected in the macular area.
CONCLUSION: ICG remains in the fundus for a period of months. The persistence duration of fluorescence from ICG is positively correlated with the concentration and the staining time of ICG. Hyaluronan is beneficial in reducing the amount of ICG residue in the macular area.
Jing Lin Zhang; Lin Lu; Yong Hao Li; Shi Yi Li; Xin Hua Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Yan ke xue bao = Eye science / "Yan ke xue bao" bian ji bu     Volume:  26     ISSN:  1000-4432     ISO Abbreviation:  Yan Ke Xue Bao     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605666     Medline TA:  Yan Ke Xue Bao     Country:  China    
Other Details:
Languages:  eng     Pagination:  44-7     Citation Subset:  IM    
GuangZhou Aier Eye Hospital Aier Eye Hospital Group.
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