Document Detail

Observation of an organism found in patients with gestational trophoblastic disease and in patients with toxemia of pregnancy.
MedLine Citation:
PMID:  6295163     Owner:  NLM     Status:  MEDLINE    
This is an initial descriptive report of observations of multiple forms of an organism found in patients with gestational trophoblastic disease and in patients with preeclampsia-eclampsia. The worm-like forms most frequently observed have an average length of 1.0 to 1.5 mm. Larva-like forms have an average length of 150 mu; primordial eggs and egg-like forms in developmental stages range from 7 to 43 mu in diameter; and sperm-like forms are 3.5 mu or slightly smaller in size. These forms have been observed in contact smears prepared from 3 ml samples of peripheral circulating blood from both groups of patients, from trophoblastic tumor tissue, from contact smears prepared from placentas of patients with preeclampsia-eclampsia, and from umbilical cord blood of infants delivered of patients with preeclampsia-eclampsia. The various forms of this organism share morphologic characteristics of several orders of helminths, i.e., hookworms, roundworms and tapeworms. The taxonomy of these forms has not yet been determined. Until the time of taxonomic classification, the various forms will be referred to as Hydatoxi lualba. We have experimental evidence that this organism has biologic activity in BALB/c mice and in beagle dogs.
J Lueck; J I Brewer; S Aladjem; M Novotny
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  145     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1983 Jan 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-26     Citation Subset:  AIM; IM    
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MeSH Terms
Blood / parasitology
Choriocarcinoma / blood
Cytological Techniques
Eclampsia / parasitology
Fetal Blood / microbiology
Hydatidiform Mole / blood
Infant, Newborn
Mice, Inbred BALB C
Placenta / microbiology
Pre-Eclampsia / parasitology*
Pregnancy Complications / parasitology*
Pregnancy Complications, Neoplastic / parasitology*
Trophoblastic Neoplasms / parasitology*
Uterine Neoplasms / parasitology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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