Document Detail

Observation of hepatohilar peribiliary vascular plexus with complete absence of hepatic artery blood supply in rats.
MedLine Citation:
PMID:  18089397     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to examine the morphologic changes in the hepatohilar peribiliary vascular plexus (PVP) and the pathology of the bile duct walls after cessation of hepatic artery blood supply in mice. MATERIALS AND METHODS: Sprague-Dawley (SD) experimental mice were randomly divided into a control and a treatment group. The morphological structure of the hepatohilar PVP after cessation of blood supply was observed using ink perfusion transparency management with computerized 3 dimensional reconstruction. The inner layer of the PVP was analyzed quantitatively and pathological examination was performed on the bile duct wall. RESULTS: The treatment group showed disorder of the 3-dimensional hepatohilar PVP structure with a markedly reduced number of micrangium in the inner layer (P<.01). The number of arterioles in the inner layer of PVP also trended downward (P<.05) and there was chronic hyperplastic inflammation in each layer of the vascular wall. CONCLUSION: Without an arterial blood supply containing a high oxygen content, the morphologic structure of the PVP changes, producing consequent pathology in the bile duct wall.
W G Li; S X Hu; B D Xue; Z G Jiang; Z Q Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation proceedings     Volume:  39     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-19     Completed Date:  2008-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3424-8     Citation Subset:  IM    
Department of Hepatobiliary Pancreas and Vessel Surgery, Xiamen First Hospital attached to Fujian Medical University, Xiamen, People's Republic of China.
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MeSH Terms
Bile Ducts, Intrahepatic / anatomy & histology,  blood supply*
Hepatic Artery* / anatomy & histology
Image Processing, Computer-Assisted
Liver Circulation*
Rats, Sprague-Dawley

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