Document Detail

The observation of phenotypic changes of Schwann cells after rat sciatic nerve injury.
MedLine Citation:
PMID:  20047518     Owner:  NLM     Status:  MEDLINE    
To describe the phenotypic changes of Schwann cells during nerve regeneration, we made two different neurorrhaphy models after rat sciatic nerves injury, the epineurium neurorrhaphy and small gap bridging suture. Then, at selected time points after surgery (1d, 3d, 5d, 7d, 2 weeks, 3 weeks), the materials were drawn for detecting the expression of GFAP, Sox2, Krox20 by immunofluorescence. GFAP is expressed in non-myelin-forming Schwann cells and Krox20 is a marker for myelin-forming cells in the adult nerve. Sox2 is a marker for neural stem and progenitor cells. Our findings showed the rule of phenotypic changes of Schwann cells during nerve regeneration. Furthermore, the difference in the phenotypic changes of Schwann cells between two operation methods indicated that the small gap changes the regenerated microenvironment and may be one of the reasons that small gap bridging suture is superior to the epineurium suture.
Jin Wang; Peixun Zhang; Yanhua Wang; Yuhui Kou; Hongbo Zhang; Baoguo Jiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial cells, blood substitutes, and immobilization biotechnology     Volume:  38     ISSN:  1532-4184     ISO Abbreviation:  Artif Cells Blood Substit Immobil Biotechnol     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-19     Completed Date:  2010-06-10     Revised Date:  2010-09-07    
Medline Journal Info:
Nlm Unique ID:  9431307     Medline TA:  Artif Cells Blood Substit Immobil Biotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  24-8     Citation Subset:  IM    
Department of Trauma and Orthopedics, People's Hospital, Peking University, South Xi-Zhi-Men Street 11, Beijing, China.
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MeSH Terms
Anastomosis, Surgical*
Antigens, Differentiation / metabolism
Cell Differentiation
Early Growth Response Protein 2 / metabolism
Glial Fibrillary Acidic Protein / metabolism
Nerve Regeneration
Peripheral Nerves / injuries,  pathology*,  surgery
Rats, Sprague-Dawley
SOXB1 Transcription Factors / metabolism
Schwann Cells / metabolism*,  pathology*
Sciatic Nerve / injuries,  pathology*,  surgery
Reg. No./Substance:
0/Antigens, Differentiation; 0/Early Growth Response Protein 2; 0/Glial Fibrillary Acidic Protein; 0/SOXB1 Transcription Factors; 0/Sox2 protein, rat
Erratum In:
Artif Cells Blood Substit Immobil Biotechnol. 2010 Apr;38(2):113

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