Document Detail


Objectively measured perinatal exposure to meperidine and benzodiazepines in Finland.
MedLine Citation:
PMID:  8162674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We measured concentrations of meperidine and benzodiazepines in the umbilical serum of all live neonates born in Finland during a single week. Of the neonates, 31.1% were exposed to meperidine or benzodiazepines or both. One hundred twenty-one mothers of the 261 neonates exposed to meperidine were not recorded in the Finnish Medical Birth Registry as having received analgesic drugs. Infants born to primiparous mothers were more likely to be exposed. The exposures were associated with the type of delivery: vacuum extraction with a high proportion of neonates exposed to meperidine and elective caesarean section with a high proportion of neonates exposed to benzodiazepines. The exposures were influenced by the method of obstetric analgesia: epidural blockade was associated with more frequent exposure to meperidine. No significant circadian variation in exposures was detected. Validation of birth registry data is imperative before they are used for pharmacoepidemiologic studies.
Authors:
A H Bardy; P Lillsunde; V K Hiilesmaa; T Seppälä
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pharmacology and therapeutics     Volume:  55     ISSN:  0009-9236     ISO Abbreviation:  Clin. Pharmacol. Ther.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-05-26     Completed Date:  1994-05-26     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372741     Medline TA:  Clin Pharmacol Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-6     Citation Subset:  AIM; IM    
Affiliation:
Laboratory of Pharmacology and Toxicology, University of Helsinki, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Analgesia, Obstetrical*
Benzodiazepines / blood*,  pharmacokinetics
Circadian Rhythm
Data Interpretation, Statistical
Female
Finland
Humans
Infant, Newborn / blood*
Maternal-Fetal Exchange
Meperidine / blood*,  pharmacokinetics
Pregnancy
Registries
Umbilical Veins
Chemical
Reg. No./Substance:
12794-10-4/Benzodiazepines; 57-42-1/Meperidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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