Document Detail

Objective and subjective measurements of cutaneous inflammation after a novel hyaluronic acid injection.
MedLine Citation:
PMID:  18547174     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hyaluronic acid (HA) dermal fillers are commonly used to minimize the appearance of facial lines and wrinkles. However, after the injection of HA, there is normally a mild inflammatory reaction. All published studies to date have measured this unwanted side effect by subjective means only. OBJECTIVE: The primary objective was to determine the magnitude and duration of the inflammation induced by injection of a novel HA using objective and subjective means. MATERIALS AND METHODS: The study was an open study in 25 normal volunteer subjects. All subjects had a single injection and were assessed objectively using an erythema meter and infrared thermometer and subjectively using established clinical scales. RESULTS: The erythema meter and the infrared thermometer objectively measured the mild cutaneous inflammation, which was transitory in nature. These objective measurements correlated well with the subjective clinical scores. CONCLUSIONS: The results of this study show that the erythema meter and the infrared thermometer are effective tools to objectively measure mild inflammation post-HA injection.
Harryono Judodihardjo; Peter Dykes
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]     Volume:  34 Suppl 1     ISSN:  1524-4725     ISO Abbreviation:  Dermatol Surg     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-12     Completed Date:  2008-08-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9504371     Medline TA:  Dermatol Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S110-4     Citation Subset:  IM    
The Cellite Clinic Ltd, Cardiff, UK.
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MeSH Terms
Biocompatible Materials / administration & dosage,  adverse effects*
Cosmetic Techniques / adverse effects*
Edema / chemically induced,  diagnosis
Erythema / chemically induced,  diagnosis
Hyaluronic Acid / administration & dosage,  adverse effects*
Inflammation / chemically induced,  diagnosis*
Injections, Intradermal
Middle Aged
Pain / chemically induced,  diagnosis
Pain Measurement
Skin / pathology
Skin Aging
Skin Temperature
Statistics, Nonparametric
Reg. No./Substance:
0/Biocompatible Materials; 9004-61-9/Hyaluronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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