Document Detail

Objective and subjective in vivo comparison of two emollient products.
MedLine Citation:
PMID:  22956880     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Few studies have directly compared the effectiveness of different emollients in vivo, and the important matter of patient preference is generally overlooked.
METHODS: We report the results of an assessor-blinded, bilateral, concurrent comparison of two emollient pharmaceutical presentations, ie, Doublebase gel (DB) and Aqueous cream BP (AC), applied by 20 participants three times daily for 7 consecutive days. The primary efficacy endpoint was cumulative improvement in skin hydration measured by corneometry on days 1, 3, and 5 immediately before the first application and approximately 2 hours after the third application of the day. Secondary endpoints were investigator assessment of skin condition at these time points and participant assessment of product acceptability at the end of the study.
RESULTS: Both products increased skin hydration, but the effect of AC was relatively modest, with morning values readily returning to pretreatment levels. Hydration levels were higher for DB gel, maintained at all time points, and showed stepwise, cumulative increases over the 7 days of use. Overall patient satisfaction scores were higher for DB gel, and especially for "consistency," "ease of use," and "ease of absorption into the skin." Eighty-five percent of participants expressed a desire to use DB gel again as compared with 40% for AC.
Jasmina Djokic-Gallagher; Phil Rosher; Jennine Walker; Valerie Hart
Publication Detail:
Type:  Journal Article     Date:  2012-08-08
Journal Detail:
Title:  Clinical, cosmetic and investigational dermatology     Volume:  5     ISSN:  1178-7015     ISO Abbreviation:  Clin Cosmet Investig Dermatol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-07     Completed Date:  2012-10-02     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101543449     Medline TA:  Clin Cosmet Investig Dermatol     Country:  New Zealand    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  -    
Research and Development Department, Dermal Laboratories Ltd, Hitchin.
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