Document Detail


Objective response of multiple myeloma to cyclosporin A.
MedLine Citation:
PMID:  7696923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two patients with advanced multiple myeloma were treated with oral low-dose cyclosporin A. one without other therapy and one in conjunction with chemotherapy to which the patient had been previously unresponsive. Both patients had objective laboratory and clinical responses. In the patient treated with cyclosporin A alone, decreasing serum IL-6 and beta-2-microglobulin levels fell as the clinical response evolved. Cyclosporin A deserves further evaluation in the therapy of multiple myeloma.
Authors:
P H Wiernik; J P Dutcher; A N Leaf; Z Liao; E Paietta; D L Rosenstreich
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  16     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-04     Completed Date:  1995-05-04     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  167-70     Citation Subset:  IM    
Affiliation:
Department of Oncology and Medicine, Albert Einstein Cancer Center, Montefiore Medical Center, Bronx, New York.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cyclosporine / administration & dosage,  therapeutic use*
Dexamethasone
Doxorubicin / administration & dosage
Humans
Male
Middle Aged
Multiple Myeloma / drug therapy*
Vincristine / administration & dosage
Grant Support
ID/Acronym/Agency:
P30CA13330/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/VAD protocol; 23214-92-8/Doxorubicin; 50-02-2/Dexamethasone; 57-22-7/Vincristine; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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