| Objective measures of motor dysfunction after compression spinal cord injury in adult rats: Correlations with locomotor rating scores. | |
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MedLine Citation:
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PMID: 21428717 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Precise assessment of motor deficits after traumatic spinal cord injury (SCI) in rodents is crucial for understanding the mechanisms of functional recovery and testing therapeutic approaches. Here we analyzed the applicability to a rat SCI model of an objective approach, the single-frame motion analysis, created and used for functional analysis in mice. Adult female Wistar rats were subjected to graded compression of the spinal cord. Recovery of locomotion was analyzed using video recordings of beam walking and inclined ladder climbing. Three out of 4 parameters used in mice appeared suitable: the foot-stepping angle (FSA) and the rump-height index (RHI) measured during beam walking and estimating paw placement and body weight support, respectively, and the number of correct ladder steps (CLS) assessing skilled limb movements. These parameters, similar to the Basso, Beattie and Bresnahan (BBB) locomotor rating scores, correlated with lesion volume and showed significant differences between moderately and severely injured rats at 1-9 weeks after SCI. The beam parameters, but not CLS, correlated well with the BBB scores within ranges of poor and good locomotor abilities. FSA co-varied with RHI only in the severely impaired rats while RHI and CLS were barely correlated. Our findings suggest that the numerical parameters estimate, as intended by design, predominantly different aspects of locomotion. The use of these objective measures combined with BBB rating provides a time- and cost-efficient opportunity for versatile and reliable functional evaluations in both severely and moderately impaired rats combining clinical assessment with precise numerical measures. |
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Authors:
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Joerg Semler; Katharina Wellmann; Felicitas Wirth; Gregor Stein; Srebrina Angelova; Mahak Ashrafi; Greta Schempf; Janina Ankerne; Ozlem Ozsoy; Umut Ozsoy; Eckhard Schoenau; Doychin Nikolov Angelov; Andrey Irintchev |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-23 |
Journal Detail:
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Title: Journal of neurotrauma Volume: - ISSN: 1557-9042 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Cologne, Germany; joerg.semler@uk-koeln.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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