Document Detail

Objective evaluation of the quality of voice following radiation therapy for T1 glottic cancer.
MedLine Citation:
PMID:  9424005     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Radiation therapy is commonly considered the treatment of choice for T1 glottic cancer. While it is generally believed that the quality of voice following irradiation is quite satisfactory, few studies have reported the results of objective assessment of voice after radiation therapy. PURPOSE: To objectively evaluate the quality of voice following radiation therapy for T1 glottic cancer. MATERIALS AND METHODS: The voices of 12 patients treated for T1 glottic cancer with radiation therapy were evaluated by acoustic analysis and speech aerodynamic studies. Eleven patients received between 6300 and 6665 cGy at a daily fraction size of 180-225 cGy. One patient received 7000 cGy at a daily fraction size of 200 cGy. Evaluation of the quality of voice was done 3 months to 7 years following completion of radiation therapy. RESULTS: The number of patients who scored abnormal values for the measurements of fundamental frequency, jitter, shimmer and harmonic to noise ratio was 2, 10, 4 and 3, respectively. The number of patients who scored abnormal values for transglottic airflow rate, subglottal pressure and glottal resistance was 12, 8 and 9, respectively. None of the studied patients scored normal values in all given tests. CONCLUSION: Although radiation therapy cures a high proportion of patients with T1 glottic cancer, the quality of voice does not return to normal following treatment.
A Aref; J Dworkin; S Devi; L Denton; J Fontanesi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology     Volume:  45     ISSN:  0167-8140     ISO Abbreviation:  Radiother Oncol     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-01-28     Completed Date:  1998-01-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8407192     Medline TA:  Radiother Oncol     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  149-53     Citation Subset:  IM    
Department of Radiation Oncology, Wayne State University, Karmanos Cancer Institute/Harper Hospital, Detroit, MI 48201, USA.
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MeSH Terms
Cobalt Radioisotopes / therapeutic use*
Dose-Response Relationship, Radiation
Follow-Up Studies
Glottis / physiopathology,  radiation effects*
Laryngeal Neoplasms / physiopathology,  radiotherapy*
Neoplasm Staging
Retrospective Studies
Time Factors
Voice Quality / physiology,  radiation effects*
Reg. No./Substance:
0/Cobalt Radioisotopes

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