| Objective selection of high-frequency power Doppler wall filter cutoff velocity for regions of interest containing multiple small vessels. | |
| | |
MedLine Citation:
|
PMID: 20236878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
High-frequency (> 20 MHz) power Doppler ultrasound is frequently used to quantify vascularity in preclinical studies of small animal angiogenic models, but quantitative images can be difficult to obtain in the presence of flow artifacts. To improve flow quantification, color pixel density (CPD) can be plotted as a function of wall filter cutoff velocity to produce a wall-filter selection curve that can be used to estimate actual vascular volume fraction. A mathematical model based on receiver operating characteristic statistics is developed to study the behavior of wall-filter selection curves. The model is compared to experimental data acquired with a 30-MHz transducer and a custom-designed multiple-vessel flow phantom capable of mimicking a range of blood vessel sizes (200-300 microm), blood flow velocities (1-10 mm/s), and blood vessel orientations. At high flow rates, wall-filter selection curves for multiple-vessel regions include a plateau whose CPD corresponds with the total vascular volume fraction. Conversely, the vascular volume fraction of a subset of vessels is obtained at low flow rates. Detection of the volume fraction of all vessels is ensured when a plateau is > 0.5 mm/s in length and begins at a wall filter cutoff < 2 mm/s. |
| | |
Authors:
|
Stephen Z Pinter; James C Lacefield |
Related Documents
:
|
19867898 - Studies on the circulation in man : xii. a study of inequalities in the blood flow in t... 16105508 - Improved stem cell mr detectability in animal models by modification of the inhalation ... 19362568 - Electrokinetic effect of the endothelial glycocalyx layer on two-phase blood flow in sm... 17282958 - Cortical vascular blood flow pattern by laser speckle imaging. 19070758 - The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized c... 19867898 - Studies on the circulation in man : xii. a study of inequalities in the blood flow in t... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-15 |
Journal Detail:
|
Title: IEEE transactions on medical imaging Volume: 29 ISSN: 1558-254X ISO Abbreviation: IEEE Trans Med Imaging Publication Date: 2010 May |
Date Detail:
|
Created Date: 2010-07-27 Completed Date: 2011-02-04 Revised Date: 2012-04-24 |
Medline Journal Info:
|
Nlm Unique ID: 8310780 Medline TA: IEEE Trans Med Imaging Country: United States |
Other Details:
|
Languages: eng Pagination: 1124-39 Citation Subset: IM |
Affiliation:
|
Biomedical Engineering Graduate Program and Robarts Research Institute, University ofWestern Ontario, London, ON N6A 5K8, Canada. spinter@ieee.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Artifacts Blood Flow Velocity Blood Vessels / ultrasonography* Image Interpretation, Computer-Assisted / methods* ROC Curve Software Ultrasonography, Doppler, Color / methods* Vascular Surgical Procedures / instrumentation |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Automatic parameter selection for multimodal image registration.
Next Document: Band-restricted estimation of noise variance in filtered backprojection reconstructions using repeat...