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Objective Habitual Physical Activity and Estradiol Levels in Obese Latina Adolescents.
MedLine Citation:
PMID:  23038707     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Lifetime physical activity (PA) is associated with decreased breast cancer (BC) risk; reports suggest that PA during adolescence contributes strongly to this relationship. PA lowers production of sex hormones, specifically estradiol, or decreases insulin resistance (IR), thereby lowering risk. Overweight Latina adolescents are insulin resistant and exhibit low levels of PA, potentially increasing their future BC risk. METHODS: 37 obese Latina adolescents (15.7 ± 1.1 yrs) provided measures of PA using accelerometry; plasma follicular phase estradiol, sex-hormone binding globulin, total and free testosterone, dehydroepiandrosterone-sulfate (DHEAS); IR using HOMA-IR; body composition via DEXA. Partial correlations and stepwise linear regressions assessed cross-sectional relationships between sex hormones, IR and PA. Body composition, and age were included a priori as covariates. RESULTS: Estradiol was negatively associated with accelerometer counts per minute (CPM) (r= -0.4; p=0.02), percent time spent in moderate PA (%MPA) (r= -0.5; p=0.006), and percent time in moderate or vigorous PA (%MVPA) (r= -0.5; p=0.007). DHEAS was positively associated with CPM (r=0.4, p=0.009), %MPA (r=0.3, p=0.04), and %MVPA (r=0.3, p=0.04). Other sex hormones and IR were not associated with PA measures. CONCLUSION: This study is the first to show that higher habitual PA was inversely associated with estradiol in obese adolescents.
Authors:
Lauren Elizabeth Gyllenhammer; Amanda K Vanni; Courtney Erin Byrd-Williams; Marc Kalan; Leslie Bernstein; Jaimie Davis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  Journal of physical activity & health     Volume:  -     ISSN:  1543-5474     ISO Abbreviation:  J Phys Act Health     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189457     Medline TA:  J Phys Act Health     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Preventive Medicine, University of Southern California, Los Angeles, CA.
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