Document Detail


Object recognition memory: neurobiological mechanisms of encoding, consolidation and retrieval.
MedLine Citation:
PMID:  18499253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tests of object recognition memory, or the judgment of the prior occurrence of an object, have made substantial contributions to our understanding of the nature and neurobiological underpinnings of mammalian memory. Only in recent years, however, have researchers begun to elucidate the specific brain areas and neural processes involved in object recognition memory. The present review considers some of this recent research, with an emphasis on studies addressing the neural bases of perirhinal cortex-dependent object recognition memory processes. We first briefly discuss operational definitions of object recognition and the common behavioural tests used to measure it in non-human primates and rodents. We then consider research from the non-human primate and rat literature examining the anatomical basis of object recognition memory in the delayed nonmatching-to-sample (DNMS) and spontaneous object recognition (SOR) tasks, respectively. The results of these studies overwhelmingly favor the view that perirhinal cortex (PRh) is a critical region for object recognition memory. We then discuss the involvement of PRh in the different stages--encoding, consolidation, and retrieval--of object recognition memory. Specifically, recent work in rats has indicated that neural activity in PRh contributes to object memory encoding, consolidation, and retrieval processes. Finally, we consider the pharmacological, cellular, and molecular factors that might play a part in PRh-mediated object recognition memory. Recent studies in rodents have begun to indicate the remarkable complexity of the neural substrates underlying this seemingly simple aspect of declarative memory.
Authors:
Boyer D Winters; Lisa M Saksida; Timothy J Bussey
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-04-24
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  32     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-09-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1055-70     Citation Subset:  IM    
Affiliation:
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. bwinters@uoguelph.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / physiology*
Discrimination (Psychology) / physiology*
Hippocampus / physiology
Humans
Learning / physiology
Memory / physiology*
Mental Recall / physiology
Pattern Recognition, Physiological / physiology*
Recognition (Psychology) / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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