Document Detail


an Obituary for GFR as the main marker for kidney function?
MedLine Citation:
PMID:  22141430     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This publication comments on the recently published findings of a study by Eloot et al. (cJASN, 6: 1266-1273, 2011) that evaluated the correlation between several formulae for calculating estimated GFR (eGFR) and different low molecular weight uremic toxins; eGFRs were based on serum creatinine (SCrea), cystatin C (Cys C), or a combination of both. Unexpectedly, the correlations for the different solutes were highly inconsistent, irrespective of the eGFR formula. On the other hand, the different eGFR formulae gave consistent results per solute. Correlation coefficients for some solutes were low (hippuric acid, p-cresylsulfate, indole acetic acid, uric acid, asymmetric dimethylarginine) to nonsignificant (carboxy-methyl-propyl-furanpropionic acid). These data point to the fact that eGFR is a deceiving predictor of uremic solute concentration and their biological action; this inconsistency is very likely the result of the impact of other factors affecting concentration, such as tubular secretion, generation by intestinal flora and metabolism.
Authors:
Raymond Vanholder; Sunny Eloot; Eva Schepers; Nathalie Neirynck; Griet Glorieux; Ziad Massy
Publication Detail:
Type:  Editorial     Date:  2011-12-06
Journal Detail:
Title:  Seminars in dialysis     Volume:  25     ISSN:  1525-139X     ISO Abbreviation:  Semin Dial     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-01-25     Completed Date:  2012-07-10     Revised Date:  2013-07-16    
Medline Journal Info:
Nlm Unique ID:  8911629     Medline TA:  Semin Dial     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-14     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / metabolism
Creatinine / metabolism
Cresols / metabolism
Cystatin C / metabolism
Glomerular Filtration Rate / physiology*
Humans
Kidney Failure, Chronic / metabolism,  physiopathology*
Kidney Function Tests
Severity of Illness Index
Chemical
Reg. No./Substance:
0/4-cresol sulfate; 0/Biological Markers; 0/Cresols; 0/Cystatin C; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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