| Obestatin: A New Element for Mineral Metabolism and Inflammation in Patients on Hemodialysis. | |
| | |
MedLine Citation:
|
PMID: 21282963 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: Obestatin plays a key role in the process of energy balance maintenance with an anorectic effect. The main aim of the study was to evaluate obestatin in uremic patients to determine whether it is correlated with nutritional and inflammatory status. Methods: We studied plasma obestatin in uremic patients (n = 50) undergoing hemodialysis therapy and in healthy subjects. Plasma obestatin was measured using an ELISA kit. Results: Obestatin levels in uremic patients were lower than in healthy subjects (p < 0.0001). Patients with a body mass index (BMI) >23 had lower obestatin levels than those with a BMI <23 (p = 0.001). After multivariate analysis, direct correlations were maintained between obestatin and high-sensitivity C-reactive protein (β = 0.68, p < 0.0001) and total alkaline phosphatases (β = 0.30, p = 0.03), while inverse correlations were found with iron (β = -0.32, p = 0.002) and calcium-phosphorous product (β = -0.40, p = 0.001). Conclusions: Based on the present observational data, obestatin might be implicated in the inflammatory state and the disturbances of calcium/phosphate metabolism of hemodialysis patients. However, further studies are warranted to determine whether this hormone plays a key role in contributing to malnutrition and to the chronic inflammatory process. |
| | |
Authors:
|
Antonio Lacquaniti; Davide Bolignano; Valentina Donato; Valeria Chirico; Adolfo Romeo; Saverio Loddo; Michele Buemi |
Related Documents
:
|
15591483 - The management and investigation of elderly patients with acute coronary syndromes with... 6994313 - Comparison of propranolol and inderal l.a. in patients with angina. 20043173 - Chemosensory function in wegener's granulomatosis: a preliminary report. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-1-29 |
Journal Detail:
|
Title: Kidney & blood pressure research Volume: 34 ISSN: 1423-0143 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-2-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9610505 Medline TA: Kidney Blood Press Res Country: - |
Other Details:
|
Languages: ENG Pagination: 104-110 Citation Subset: - |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Department of Internal Medicine, University of Messina, Messina, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Allergen-Induced Accumulation of CD68,CD123(+) Dendritic Cells in the Nasal Mucosa.
Next Document: Nationwide Population-Based Epidemiologic Study of Cryptococcal Meningitis in Taiwan.