Document Detail


Obesity, weight change, and functional decline in peripheral arterial disease.
MedLine Citation:
PMID:  16765239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Our objectives were to determine whether obesity is associated with a greater functional decline compared with the ideal body mass index (BMI) among persons with peripheral arterial disease (PAD) and to determine the associations between weight gain and loss and functional declines in PAD. We hypothesized that baseline obesity and weight gain during follow-up would each be associated with functional declines in persons with PAD.
METHODS: The design was a prospective cohort study. The subjects were 389 men and women with PAD (mean ankle-brachial index, 0.65 +/- 0.14) who were followed up prospectively for a median of 48 months. The main outcome measures were functional assessments (6-minute walk, usual- and rapid-paced 4-m walking speed, and summary performance score). Weight and height were measured at baseline and annually. Results were adjusted for age, sex, race, comorbidities, ankle-brachial index, education, leg symptoms, exercise status, depressive symptoms, pack-years of cigarette smoking, prior-year functioning, and patterns of missing data.
RESULTS: Compared with those with a baseline BMI between 20 and 25 kg/m2, PAD participants with baseline BMI greater than 30 kg/m2 had a significantly greater average annual decline in 6-minute walk performance (-13.1 vs -26.5 m/y; P = .004), usual-paced 4-m walking velocity (-0.028 vs -0.055 m/s per year; P = .024), and fast-paced 4-m walking velocity (-0.053 vs -0.086 m/s per year; P = .012). Persons with weight gain between 5 and 10 pounds after baseline who walked for exercise regularly had significantly less decline in the 6-minute walk than persons without significant weight change who did not walk for exercise (P = .04).
CONCLUSIONS: Obesity is associated with functional decline in persons with PAD. Walking exercise may protect against functional decline in PAD persons with modest weight gain.
Authors:
Mary M McDermott; Michael H Criqui; Luigi Ferrucci; Jack M Guralnik; Lu Tian; Kiang Liu; Philip Greenland; Jin Tan; Joseph R Schneider; Elizabeth Clark; William H Pearce
Related Documents :
9008669 - Reliability of physical performance measures in nursing home residents with alzheimer's...
15632669 - Immune response to a 30-minute walk.
18575869 - Pedestrian locomotion energetics and gait characteristics of a diving bird, the great c...
16097499 - Cardioventilatory responses during real or imagined walking at low speed.
12760409 - The influence of rotational exercises on freezing in parkinson's disease.
8782119 - Ontogeny of bipedal locomotion: walking and running in the chick.
1206469 - Enhancement of experienced sexual arousal in response to erotic stimuli through misattr...
12454429 - The influence of exercise on bone morphogenic enzyme activity of immature equine subcho...
9179309 - Middle cerebral artery blood velocity, arterial diameter and muscle sympathetic nerve a...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  43     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-07-13     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1198-204     Citation Subset:  IM    
Affiliation:
Department of Medicine, Northwestern University's Feinberg School of Medicine, Chicago, IL 60611, USA. mdm608@northwestern.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Body Mass Index
Female
Humans
Leg / blood supply*
Linear Models
Longitudinal Studies
Male
Middle Aged
Obesity / physiopathology*
Peripheral Vascular Diseases / physiopathology*
Prospective Studies
Walking / physiology*
Weight Gain
Weight Loss
Grant Support
ID/Acronym/Agency:
R01-HL073351/HL/NHLBI NIH HHS; R01-HL58099/HL/NHLBI NIH HHS; R01-HL64739/HL/NHLBI NIH HHS; RR-00048/RR/NCRR NIH HHS; Z99 AG999999/AG/NIA NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metabolic syndrome impairs physical function, health-related quality of life, and peripheral circula...
Next Document:  Effect of a clinical pharmacy service on lipid control in patients with peripheral arterial disease.