Document Detail


Obesity treatment: novel peripheral targets.
MedLine Citation:
PMID:  20002077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our knowledge of the complex mechanisms underlying energy homeostasis has expanded enormously in recent years. Food intake and body weight are tightly regulated by the hypothalamus, brainstem and reward circuits, on the basis both of cognitive inputs and of diverse humoral and neuronal signals of nutritional status. Several gut hormones, including cholecystokinin, glucagon-like peptide-1, peptide YY, oxyntomodulin, amylin, pancreatic polypeptide and ghrelin, have been shown to play an important role in regulating short-term food intake. These hormones therefore represent potential targets in the development of novel anti-obesity drugs. This review focuses on the role of gut hormones in short- and long-term regulation of food intake, and on the current state of development of gut hormone-based obesity therapies.
Authors:
Benjamin C T Field; Owais B Chaudhri; Stephen R Bloom
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  68     ISSN:  1365-2125     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-07-29     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  830-43     Citation Subset:  IM    
Affiliation:
Department of Investigative Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Amyloid / therapeutic use
Anti-Obesity Agents / therapeutic use*
Appetite Depressants / therapeutic use*
Appetite Regulation / drug effects*
Cholecystokinin / therapeutic use
Eating / physiology
Energy Metabolism / physiology
Gastrointestinal Agents / therapeutic use*
Ghrelin / therapeutic use
Humans
Islet Amyloid Polypeptide
Obesity / drug therapy*
Oxyntomodulin / therapeutic use
Pancreatic Polypeptide / therapeutic use
Peptide YY / therapeutic use
Chemical
Reg. No./Substance:
0/Amyloid; 0/Anti-Obesity Agents; 0/Appetite Depressants; 0/Gastrointestinal Agents; 0/Ghrelin; 0/Islet Amyloid Polypeptide; 0/Oxyntomodulin; 106388-42-5/Peptide YY; 59763-91-6/Pancreatic Polypeptide; 9011-97-6/Cholecystokinin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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