Document Detail


Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals.
MedLine Citation:
PMID:  21248185     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background.
OBJECTIVE: The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight.
DESIGN: A meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (n(max) = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis of 6 genome-wide association studies for birth weight (n(max) = 10,623); and 3) all published data (n(max) = 14,837).
RESULTS: Only the MTCH2 and FTO loci showed a nominally significant association with birth weight. The BMI-increasing allele of the MTCH2 variant (rs10838738) was associated with a lower birth weight (β ± SE: -13 ± 5 g/allele; P = 0.012; n = 23,680), and the BMI-increasing allele of the FTO variant (rs1121980) was associated with a higher birth weight (β ± SE: 11 ± 4 g/allele; P = 0.013; n = 28,219). These results were not significant after correction for multiple testing.
CONCLUSIONS: Obesity-susceptibility loci have a small or no effect on weight at birth. Some evidence of an association was found for the MTCH2 and FTO loci, ie, lower and higher birth weight, respectively. These findings may provide new insights into the underlying mechanisms by which these loci confer an increased risk of obesity.
Authors:
Tuomas O Kilpeläinen; Marcel den Hoed; Ken K Ong; Anders Grøntved; Soren Brage; ; Karen Jameson; Cyrus Cooper; Kay-Tee Khaw; Ulf Ekelund; Nicholas J Wareham; Ruth J F Loos
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't     Date:  2011-01-19
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  93     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-22     Completed Date:  2011-05-26     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  851-60     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Alleles*
Birth Weight / genetics*
Body Mass Index*
Female
Genetic Loci*
Genome-Wide Association Study / methods
Humans
Male
Membrane Transport Proteins / genetics*
Middle Aged
Mitochondrial Membrane Transport Proteins
Mitochondrial Proteins / genetics*
Obesity / genetics*
Proteins / genetics*
Young Adult
Grant Support
ID/Acronym/Agency:
076467//Wellcome Trust; 74882//Medical Research Council; G0401527//Medical Research Council; G0701863//Medical Research Council; G1000143//Medical Research Council; MC_U106179471//Medical Research Council; MC_U106179472//Medical Research Council; MC_U106179473//Medical Research Council; MC_U106188470//Medical Research Council; MC_UP_A620_1014//Medical Research Council; //Cancer Research UK
Chemical
Reg. No./Substance:
0/FTO protein, human; 0/MTCH2 protein, human; 0/Membrane Transport Proteins; 0/Mitochondrial Membrane Transport Proteins; 0/Mitochondrial Proteins; 0/Proteins
Investigator
Investigator/Affiliation:
Rachel M Freathy / ; Dennis O Mook-Kanamori / ; Ulla Sovio / ; Inga Prokopenko / ; Nicholas J Timpson / ; Diane J Berry / ; Nicole M Warrington / ; Elisabeth Widen / ; Jouke Jan Hottenga / ; Marika Kaakinen / ; Leslie A Lange / ; Jonathan P Bradfield / ; Marjan Kerkhof / ; Julie A Marsh / ; Reedik Mägi / ; Chih-Mei Chen / ; Helen N Lyon / ; Mirna Kirin / ; Linda S Adair / ; Yurii S Aulchenko / ; Amanda J Bennett / ; Judith B Borja / ; Nabila Bouatia-Naji / ; Pimphen Charoen / ; Lachlan J M Coin / ; Diana L Cousminer / ; Eco J C de Geus / ; Panos Deloukas / ; Paul Elliott / ; David M Evans / ; Philippe Froguel / ; Beate Glaser / ; Christopher J Groves / ; Anna-Liisa Hartikainen / ; Neelam Hassanali / ; Joel N Hirschhorn / ; Albert Hofman / ; Jeff M P Holly / ; Elina Hyppönen / ; Stavroula Kanoni / ; Bridget A Knight / ; Jaana Laitinen / ; Cecilia M Lindgren / ; Wendy L McArdle / ; Paul F O'Reilly / ; Craig E Pennell / ; Dirkje S Postma / ; Anneli Pouta / ; Adaikalavan Ramasamy / ; Nigel W Rayner / ; Susan M Ring / ; Fernando Rivadeneira / ; Beverley M Shields / ; David P Strachan / ; Ida Surakka / ; Anja Taanila / ; Carla Tiesler / ; Andre G Uitterlinden / ; Cornelia M van Duijn / ; Alet H Wijga / ; Gonneke Willemsen / ; Haitao Zhang / ; Jianhua Zhao / ; James F Wilson / ; Eric A P Steegers / ; Andrew T Hattersley / ; Johan G Eriksson / ; Leena Peltonen / ; Karen L Mohlke / ; Struan F A Grant / ; Hakon Hakonarson / ; Gerard H Koppelman / ; George V Dedoussis / ; Joachim Heinrich / ; Matthew W Gillman / ; Lyle J Palmer / ; Timothy M Frayling / ; Dorret I Boomsma / ; George Davey Smith / ; Chris Power / ; Vincent W V Jaddoe / ; Marjo-Riitta Jarvelin / ; Mark I McCarthy /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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